Analytical Data
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基因名
HLA-A*02:01&B2M&MAGE-A4(KVLEHVVRV) Monomer
- Application
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别名
HLA-A*0201 & B2M & MAGE-A4 (KVLEHVVRV)
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种属
Human
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表达系统
HEK293
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标签
C-Avi;C-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
AAA59606.1 (G25-I308)&P61769
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表达区间
AAA59606.1 (G25-I308)&P61769 (I21-M119)&KVLEHVVRV
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分子量
42-45 kDa and 15 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HLA-A*02:01, a major histocompatibility complex class I molecule, plays a pivotal role in the immune system by presenting peptide antigens to CD8+ T cells, thus facilitating immune responses against tumors and infections. The protein β2-microglobulin (β2M) is essential for the stability and proper functioning of HLA class I molecules. The MAGE-A4 peptide (KVLEHVVRV), derived from the melanoma-associated antigen MAGE-A4, has been identified as a target for immunotherapy due to its ability to elicit strong T cell responses in cancer patients. The study of HLA-A*02:01 in complex with β2M and the MAGE-A4 peptide is crucial for understanding how this specific antigen is presented to T cells. By producing a recombinant monomeric form of this complex, researchers aim to analyze its structural and functional characteristics in detail. This research not only enhances our understanding of T cell recognition and activation but also informs the development of targeted immunotherapies for cancers expressing MAGE-A4. Overall, the investigation of the HLA-A*02:01/β2M/MAGE-A4 complex is instrumental in elucidating the mechanisms of immune recognition and designing effective cancer vaccines or adoptive T cell therapies.
