Analytical Data
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基因名
TRBC1
- Application
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别名
T cell receptor beta constant 1; TRBC1
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种属
Human
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表达系统
HEK293
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标签
C-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P01850
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表达区间
D1-A144
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蛋白长度
Partial
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分子量
20 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TRBC1, or T-cell receptor beta chain constant region 1, plays a vital role in the adaptive immune response by encoding a component of the T-cell receptor (TCR) complex, which is crucial for T-cell recognition of antigens. Research into TRBC1 is gaining momentum due to its potential implications in immunology and cancer therapy. Abnormalities in TCR expression, including TRBC1, have been linked to various diseases, particularly cancers like leukemias and lymphomas, where T-cell malignancies arise from genetic alterations. Understanding the structure and function of TRBC1 can pave the way for novel therapeutic approaches, including TCR-engineered T cell therapies aimed at enhancing the immune system's ability to target and destroy cancer cells. Additionally, investigating TRBC1's role in immune disorders may lead to better diagnostic markers and treatment strategies. Recombinant TRBC1 proteins are increasingly used in research to elucidate its interactions and functionality within the TCR complex, contributing to a more comprehensive understanding of T-cell biology and the development of targeted immunotherapies. Such studies could ultimately lead to significant advancements in treating immune-related diseases.
