Analytical Data
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Gene name
PAK6
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简介
PAK6, a dynamic serine/threonine kinase, regulates gene transcription activated by AR or MAP2K6/MAPKK6. It phosphorylates and inhibits AR-mediated transcription, hindering ESR1-mediated transcription. PAK6 interacts with IQGAP1, suggesting a role in cytoskeleton regulation. Moreover, it protects cells from apoptosis by phosphorylating BAD, showcasing its multifaceted impact on transcriptional control and cytoskeletal dynamics. PAK6 Protein, Human (His) is the recombinant human-derived PAK6 protein, expressed by E. coli , with N-6*His labeled tag.
- Application
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Alternative Names
PAK6; Serine/threonine-protein kinase PAK 6; PAK-5; p21-activated kinase 6; PAK-6
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Species
Human
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Source
E. coli
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Tag
N-6*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9NQU5
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Expression Region
G383-Y674
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Protein Length
Partial
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PAK6, or p21-activated kinase 6, is a member of the PAK family of serine/threonine kinases, which play critical roles in various cellular processes, including cell motility, proliferation, and survival. Research into PAK6 has gained significant attention due to its involvement in neuronal development and its potential implications in neurodegenerative diseases. Unlike other PAK family members, PAK6 is predominantly expressed in the brain, suggesting a specialized function in cognitive processes and neuronal signaling pathways. Studies have shown that PAK6 interacts with several key proteins, including those involved in synaptic plasticity, which is vital for learning and memory. Moreover, dysregulation of PAK6 has been linked to conditions such as cancer and Alzheimer’s disease, highlighting its relevance in both developmental biology and pathology. Given its unique expression profile and functional attributes, PAK6 is emerging as a promising target for therapeutic interventions aimed at modulating synaptic function and addressing neural deficits. Investigating the mechanisms of PAK6 action, including its signaling pathways and regulatory networks, is essential for understanding its contribution to neuronal health and disease. Thus, the study of PAK6 recombinant protein not only aids in elucidating its biological roles but may also facilitate the development of novel strategies for treating neurodegenerative disorders and related conditions.
