Analytical Data
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Gene name
ROR2
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简介
The ROR2 protein is a tyrosine protein kinase receptor that plays a critical role in early chondrocyte formation and is essential for cartilage and growth plate development. Phosphorylated YWHAB induces osteogenesis and bone formation. ROR2 Protein, Human (HEK293, Fc) is the recombinant human-derived ROR2 protein, expressed by HEK293 , with C-hFc labeled tag.
- Application
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Alternative Names
BDB; BDB1; NTRKR2; ROR2
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Species
Human
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Source
HEK293
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Tag
C-hFc
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
A1L4F5
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Expression Region
V34-G403
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Protein Length
Partial
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Molecular Weight
80-110 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ROR2 (Receptor tyrosine kinase-like orphan receptor 2) is a member of the ROR family of receptors that has gained significant attention in biomedical research due to its critical role in various biological processes, including embryonic development, bone formation, and neuronal differentiation. As a receptor, ROR2 is involved in signaling pathways that regulate cell growth and function, particularly in the context of the Wnt signaling pathway. Mutations and dysregulation of ROR2 have been linked to several developmental disorders, such as Robinow syndrome, which manifests in skeletal dysplasia and facial abnormalities. Recent studies have also suggested that ROR2 might be implicated in cancer progression, as its expression is often altered in various tumor types, contributing to tumor cell proliferation and metastasis. Consequently, the development of ROR2 recombinant proteins has emerged as a promising approach to elucidate its structure-function relationships and therapeutic potential. These proteins can be utilized to investigate ROR2's role in signaling pathways, explore its interaction with ligands and other cellular proteins, and serve as potential biomarkers or targets in cancer therapy. Understanding the functional implications of ROR2 through recombinant protein studies can pave the way for novel interventions in diseases associated with its dysregulation.
