Analytical Data
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基因名
SOS1
- Application
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别名
GF1 Protein, Human; GGF1 Protein, Human; GINGF Protein, Human; HGF Protein, Human; NS4 Protein, Human; SOS-1 Protein, Human
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种属
Human
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表达系统
Baculovirus
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q07889-1
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表达区间
K504-T1049
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氨基酸序列
KDDTNEYKHAFEIILKDENSVIFSAKSAEEKNNWMAALISLQYRSTLERMLDVTMLQEEKEEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT
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蛋白长度
Partial
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分子量
57 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SOS1 (Son of Sevenless 1) is a crucial guanine nucleotide exchange factor (GEF) that plays a pivotal role in the Ras signaling pathway, which is essential for various cellular processes, including cell proliferation, differentiation, and survival. Mutations in SOS1 have been implicated in several human diseases, most notably congenital heart defects and Noonan syndrome, a genetic disorder characterized by distinctive facial features, short stature, and increased risk of certain cancers. Given the significance of SOS1 in cellular signaling and its involvement in disease pathology, researchers have increasingly focused on the characterization and functional analysis of SOS1 recombinant proteins. These studies aim to elucidate the molecular mechanisms by which SOS1 activates Ras and to explore its potential as a therapeutic target for intervention in Ras-related disorders. The production of recombinant SOS1 protein allows for in-depth biochemical and structural studies, which are critical for understanding its interactions with Ras and other signaling molecules. Insights gained from such research can inform the development of novel therapeutic strategies aimed at modulating SOS1 activity, providing potential avenues for treating conditions associated with aberrant Ras signaling. Overall, the investigation of SOS1 recombinant proteins is a rapidly evolving field, contributing to the broader understanding of oncogenic signaling pathways and offering hope for targeted therapies in cancer and genetic disorders.
