Analytical Data
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Gene name
SLC40A1
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简介
SLC40A1 plays a pivotal role in systemic iron homeostasis by transporting Fe(2+) from cells to the bloodstream. Essential for maintaining iron balance, it enables dietary iron uptake, recycling by macrophages and erythrocytes, and controlled release from hepatocytes. In iron surplus, elevated HAMP/hepcidin levels prompt SLC40A1 degradation, limiting iron efflux into the plasma. SLC40A1 Protein, Human (HEK293) is the recombinant human-derived SLC40A1 protein, expressed by HEK293, with tag free.
- Application
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Alternative Names
Ferroportin-1; Iron-regulated transporter 1; Solute carrier family 40 member 1 ; Ferroportin; SLC40A1; FPN1, IREG1, SLC11A3; MSTP079; FPN
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Species
Human
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Source
HEK293
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Tag
Tag Free
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9NP59
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Expression Region
M1-V571
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AA Sequence
MTRAGDHNRQRGCCGSLADYLTSAKFLLYLGHSLSTWGDRMWHFAVSVFLVELYGNSLLLTAVYGLVVAGSVLVLGAIIGDWVDKNARLKVAQTSLVVQNVSVILCGIILMMVFLHKHELLTMYHGWVLTSCYILIITIANIANLASTATAITIQRDWIVVVAGEDRSKLANMNATIRRIDQLTNILAPMAVGQIMTFGSPVIGCGFISGWNLVSMCVEYVLLWKVYQKTPALAVKAGLKEEETELKQLNLHKDTEPKPLEGTHLMGVKDSNIHELEHEQEPTCASQMAEPFRTFRDGWVSYYNQPVFLAGMGLAFLYMTVLGFDCITTGYAYTQGLSGSILSILMGASAITGIMGTVAFTWLRRKCGLVRTGLISGLAQLSCLILCVISVFMPGSPLDLSVSPFEDIRSRFIQGESITPTKIPEITTEIYMSNGSNSANIVPETSPESVPIISVSLLFAGVIAARIGLWSFDLTVTQLLQENVIESERGIINGVQNSMNYLLDLLHFIMVILAPNPEAFGLLVLISVSFVAMGHIMYFRFAQNTLGNKLFACGPDAKEVRKENQANTSVV
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Protein Length
Full Length
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Molecular Weight
55 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SLC40A1, also known as ferroportin, is a crucial transmembrane protein involved in iron homeostasis within the human body. It plays a vital role in the transport of iron from inside cells to the extracellular space, thereby facilitating its availability for various physiological processes like erythropoiesis and cellular metabolism. Dysregulation of SLC40A1 has been implicated in several iron-related disorders, including anemia of chronic disease and genetic hemochromatosis. Research has shown that mutations in the SLC40A1 gene can lead to impaired iron export, causing iron overload in macrophages and other tissues. Given the significance of iron in biological functions, the study of SLC40A1 recombinant protein is essential for understanding its structural and functional properties, including its interaction with other proteins and its role in cellular iron transport mechanisms. Recombinant SLC40A1 protein can be produced for biochemical assays and structural studies, which help elucidate the pathways of iron regulation and the molecular basis of related diseases. Furthermore, this research contributes to the development of therapeutic strategies targeting SLC40A1 to manage iron metabolism disorders effectively. As such, the investigation of SLC40A1 recombinant protein is integral to advancing our understanding of iron transport and its implications for human health.
