Analytical Data
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基因名
ULK3
- Application
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别名
Serine/threonine-protein kinase ULK3; Unc-51-like kinase 3; ULK3; Homo sapiens; Human; Kinase; Serine/threonine-protein kinase; Transferase; 2.7.11.1
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种属
Human
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表达系统
Baculovirus
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标签
N-His;N-GST
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q6PHR2-1
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表达区间
A2-Q472
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蛋白长度
Partial
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分子量
81.1 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ULK3 (Unc-51 Like Autophagy Activating Kinase 3) is a member of the Unc-51-like kinase family, which plays a pivotal role in the regulation of autophagy, a cellular process essential for maintaining cellular homeostasis, energy balance, and response to stress. Research into ULK3 has gained traction due to its involvement in various physiological and pathological processes, including development, neurodegeneration, cancer, and metabolic diseases. ULK3 is known to participate in the initiation of the autophagic process by phosphorylating key substrates, thereby influencing autophagosome formation. The study of ULK3 recombinant proteins provides significant insights into its structural and functional properties, regulatory mechanisms, and potential as a therapeutic target. By understanding its role in autophagy regulation, researchers are exploring ULK3's implications in disease contexts, including tumorigenesis and neurodegeneration. Furthermore, as a potential biomarker for certain diseases, ULK3 is of considerable interest for drug discovery and development aimed at modulating autophagic processes. Thus, the investigation of ULK3 recombinant proteins serves not only to elucidate its biological functions but also to pave the way for novel therapeutic strategies targeting autophagy-related pathways in human diseases.
