Analytical Data
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基因名
PLK4
- Application
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别名
SAK; STK18
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种属
Human
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表达系统
E. coli
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标签
Tag Free
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O00444-1
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表达区间
A2-D275
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蛋白长度
Partial
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分子量
31.3 KDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PLK4 (Polo-like kinase 4) is a crucial serine/threonine kinase that plays a significant role in cell cycle regulation and centrosome biogenesis. Recent studies have highlighted its importance in maintaining genomic stability and its involvement in various cellular processes, including mitotic spindle formation and flagella assembly. Aberrant expression of PLK4 has been linked to several cancers, making it a potential target for therapeutic intervention. Researchers have focused on the characterization of PLK4 as a recombinant protein to elucidate its functional mechanisms and interactions within cellular pathways. The production of PLK4 as a recombinant protein allows for detailed biochemical assays and structural studies, facilitating the understanding of its kinase activity and the regulation of its function. Additionally, these studies may provide insights into how PLK4's dysregulation contributes to tumorigenesis, thus paving the way for the development of targeted inhibitors for cancer treatment. Understanding the structural and functional properties of PLK4 at the protein level is critical for advancing our knowledge of its role in cancer biology and for the potential development of novel anti-cancer strategies.
