Analytical Data
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Gene name
PLK4
- Application
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Alternative Names
SAK; STK18
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Species
Human
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Source
E. coli
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Tag
Tag Free
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O00444-1
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Expression Region
A2-D275
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Protein Length
Partial
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Molecular Weight
31.3 KDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
PLK4 (Polo-like kinase 4) is a crucial serine/threonine kinase that plays a significant role in cell cycle regulation and centrosome biogenesis. Recent studies have highlighted its importance in maintaining genomic stability and its involvement in various cellular processes, including mitotic spindle formation and flagella assembly. Aberrant expression of PLK4 has been linked to several cancers, making it a potential target for therapeutic intervention. Researchers have focused on the characterization of PLK4 as a recombinant protein to elucidate its functional mechanisms and interactions within cellular pathways. The production of PLK4 as a recombinant protein allows for detailed biochemical assays and structural studies, facilitating the understanding of its kinase activity and the regulation of its function. Additionally, these studies may provide insights into how PLK4's dysregulation contributes to tumorigenesis, thus paving the way for the development of targeted inhibitors for cancer treatment. Understanding the structural and functional properties of PLK4 at the protein level is critical for advancing our knowledge of its role in cancer biology and for the potential development of novel anti-cancer strategies.
