Analytical Data
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Gene name
KAT6A
- Application
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Alternative Names
MOZ; MYST3; RUNXBP2; ZNF220
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Species
Human
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Source
E. coli
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Tag
N-Avi
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q92794
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Expression Region
G497-I780
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Protein Length
Partial
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Molecular Weight
35.6 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
KAT6A is a histone acetyltransferase that plays a crucial role in the regulation of gene expression, particularly during development and cellular differentiation. Mutations and rearrangements in the KAT6A gene have been associated with various developmental disorders, including KAT6A syndrome, characterized by intellectual disability, speech delays, and distinctive facial features. Research into KAT6A recombinant proteins has gained traction as scientists aim to understand the precise mechanisms by which KAT6A influences chromatin modifications and gene activity. These studies often focus on the protein's acetyltransferase activity, its interactions with other chromatin-associated proteins, and its role in transcriptional regulation. By expressing and purifying recombinantly produced KAT6A proteins, researchers can investigate their functional properties in vitro, providing insights into how disruptions in KAT6A activity contribute to the pathophysiology of associated disorders. This research not only enhances our understanding of KAT6A's biological functions but also has potential implications for therapeutic strategies in managing genetic disorders linked to KAT6A mutations.
