Analytical Data
-
Gene name
S100A11
-
简介
The S100A11 protein plays a crucial role in promoting keratinocyte differentiation and keratinization, suggesting its involvement in important processes related to skin development and integrity.As a disulfide-linked homodimer, S100A11 may contribute to the molecular machinery that regulates keratinocyte maturation and specialized functions.S100A11 Protein, Mouse (His) is the recombinant mouse-derived S100A11 protein, expressed by E.coli , with N-6*His labeled tag.
- Application
-
Alternative Names
Protein S100-A11; Calgizzarin; Endothelial monocyte-activating polypeptide; EMAP; Protein S100-C; S100 calcium-binding protein A11; S100a11; S100c
-
Species
Mouse
-
Source
E. coli
-
Tag
N-6*His
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
P50543
-
Expression Region
M1-I98
-
Protein Length
Full Length
-
Molecular Weight
12.0 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
S100A11 is a member of the S100 family of calcium-binding proteins, which play critical roles in various cellular processes such as proliferation, differentiation, and apoptosis. Research into S100A11 has gained significant attention due to its involvement in several pathological conditions, including cancer, inflammation, and neurodegenerative diseases. Elevated expression levels of S100A11 have been linked to tumor progression and metastasis, making it a potential biomarker and therapeutic target in oncology. The protein's ability to modulate signaling pathways, such as those involving Rac1 and the NF-κB pathway, highlights its role in the cellular response to stress and inflammatory stimuli. Furthermore, insights into the structural and functional aspects of S100A11 have been enhanced through recombinant protein production, allowing for detailed studies on its interaction with other biomolecules. Utilizing recombinant technologies has facilitated the exploration of S100A11's biochemical properties, enabling researchers to investigate its potential therapeutic applications, particularly in targeted cancer therapies and anti-inflammatory treatments. Given the increasing understanding of S100A11's multifaceted roles in health and disease, ongoing research is essential to unravel its complex functions and to harness its potential in clinical settings.
