Analytical Data
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Gene name
FLRT3
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简介
The FLRT3 protein exhibits multiple roles in cellular processes, affecting cell-cell adhesion, migration, and axonal guidance, with context-dependent attraction or repulsion.FLRT3 is critical for the spatial organization of brain neurons and also contributes to retinal blood vessel development.FLRT3 Protein, Human (HEK293, His) is the recombinant human-derived FLRT3 protein, expressed by HEK293 , with C-6*His labeled tag.
- Application
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Alternative Names
Leucine-Rich Repeat Transmembrane Protein FLRT3; Fibronectin-Like Domain-Containing Leucine-Rich Transmembrane Protein 3; FLRT3; KIAA1469
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Species
Human
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Source
HEK293
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Tag
C-6*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9NZU0
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Expression Region
K29-P528
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AA Sequence
KSCPSVCRCDAGFIYCNDRFLTSIPTGIPEDATTLYLQNNQINNAGIPSDLKNLLKVERIYLYHNSLDEFPTNLPKYVKELHLQENNIRTITYDSLSKIPYLEELHLDDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPWGLPRTIEELRLDDNRISTISSPSLQGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLVRNSLTAAPVNLPGTNLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNLPQGIFDDLDNITQLILRNNPWYCGCKMKWVRDWLQSLPVKVNVRGLMCQAPEKVRGMAIKDLNAELFDCKDSGIVSTIQITTAIPNTVYPAQGQWPAPVTKQPDIKNPKLTKDHQTTGSPSRKTITITVKSVTSDTIHISWKLALPMTALRLSWLKLGHSPAFGSITETIVTGERSEYLVTALEPDSPYKVCMVPMETSNLYLFDETPVCIETETAPLRMYNPTTTLNREQEKEPYKNPNLP
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Protein Length
Extracellular Domain
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Molecular Weight
60-110 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
FLRT3 (Fibronectin Leucine Rich Transmembrane Protein 3) is a member of the FLRT family known for its roles in cell adhesion, migration, and synaptic functions during development. Recent studies have highlighted its significance in various biological processes, including neuronal development, tissue repair, and cancer biology. The protein’s involvement in the regulation of extracellular matrix interactions and its influence on cell signaling pathways make it a critical factor in understanding developmental biology and pathophysiological conditions. Specifically, FLRT3 has been implicated in the formation and maintenance of synapses, indicating its potential role in neurodevelopmental disorders. Researchers are particularly interested in the structural and functional properties of recombinant FLRT3, which enable them to investigate its mechanism of action and interactions with other proteins or receptors. By producing FLRT3 as a recombinant protein, scientists can conduct detailed studies to elucidate its biological functions and therapeutic potential, particularly in contexts where cellular adhesion and signaling are disrupted. This research not only aids in the understanding of FLRT3's contributions to normal physiology but also offers insights into its roles in diseases such as cancer and neurodegenerative disorders. As a result, FLRT3 recombinant protein research is positioned at the intersection of developmental biology, neuroscience, and cancer research, highlighting its multidisciplinary significance and the potential for therapeutic applications.
