Analytical Data
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基因名
EXOSC8
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简介
EXOSC8 is a non-catalytic RNA exosome complex component that is critical for 3'->5' exoribonuclease activity and affects a variety of cellular RNA processing and degradation. In the nucleus, it helps stabilize the maturation of RNA species and eliminates processing by-products, non-coding transcripts and defective mRNAs, thereby preventing their export to the cytoplasm. EXOSC8 Protein, Human is the recombinant human-derived EXOSC8 protein, expressed by E. coli , with tag free.
- Application
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别名
EXOSC8; Exosome complex component RRP43; Exosome component 8; Opa-interacting protein 2; OIP-2; Ribosomal RNA-processing protein 43; p9
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种属
Human
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表达系统
E. coli
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标签
Tag Free
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q96B26
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表达区间
M1-K276
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蛋白长度
Full Length
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
EXOSC8, a core component of the RNA exosome complex, plays a crucial role in RNA processing and degradation, influencing gene expression and maintaining RNA homeostasis within cells. The exosome complex is essential for the efficient turnover of various RNA species, including mRNA, rRNA, and non-coding RNAs, thus contributing significantly to post-transcriptional regulation. Recent studies have highlighted the involvement of EXOSC8 in various cellular processes, including response to stress and cell differentiation, as well as its potential links to several diseases, such as cancer and neurodegenerative disorders. Its importance in the regulation of RNA stability and the quality control of RNA molecules underscores the need for detailed studies on EXOSC8's structure and function. Additionally, the production of recombinant EXOSC8 protein allows researchers to investigate its biochemical properties, interactions with other components of the exosome complex, and its role in RNA metabolism more thoroughly. Understanding the molecular mechanisms mediated by EXOSC8 could provide insights into therapeutic targets for diseases associated with dysregulation of RNA metabolism, making it a significant focus of ongoing research in molecular biology and genetics. Overall, the study of EXOSC8 and its functions is pivotal for elucidating the complex landscape of RNA biology and its implications in health and disease.
