Analytical Data
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基因名
NLRP5
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简介
NLRP5 is a key SCMC member that coordinates zygote progression by regulating the formation of F-actin CPL, ensuring symmetric division and spindle positioning. It directs cortical granule positioning, connects to the actin scaffold for granule localization, and contributes to actin clearance prior to oocyte exocytosis. NLRP5 Protein, Human (sf9) is the recombinant human-derived NLRP5 protein, expressed by sf9 insect cells , with tag free.
- Application
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别名
NLRP5; NACHT; LRR and PYD domains-containing protein 5; Mater protein homolog; Maternal Antigen that Embryos Require
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种属
Human
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表达系统
Baculovirus
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标签
Tag Free
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P59047
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表达区间
G227-N1200
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蛋白长度
Partial
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
NLRP5, also known as NLR family pyrin domain containing 5, is a member of the nucleotide-binding oligomerization domain-like receptors (NLRs), which play a crucial role in the innate immune response and inflammation. NLRP5 is primarily expressed in oocytes and has been implicated in various reproductive processes, including oocyte maturation and early embryonic development. Recent studies have suggested that NLRP5 may be involved in regulating cellular responses to stress and pathogen-associated molecular patterns, thus influencing immune signaling pathways. Its role in reproductive biology and immunology has made it a target for research aimed at understanding fertility and potential mechanisms underlying reproductive disorders. Furthermore, NLRP5 might contribute to the pathogenesis of certain diseases, including autoimmune conditions and infections. The development of recombinant NLRP5 proteins provides a valuable tool for investigating its structural and functional properties, enabling researchers to elucidate its mechanisms of action. By studying NLRP5 at a molecular level, scientists hope to uncover novel therapeutic strategies that could improve reproductive health and address immune-related diseases.
