Analytical Data
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Gene name
ERMAP
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简介
ERMAP protein potentially serves as a cell-adhesion or receptor molecule in erythroid cells, suggesting involvement in crucial interactions or signaling events. The precise mechanisms, ligands, and broader implications of ERMAP's activity in erythroid cell biology require further investigation. Unraveling ERMAP's function may provide insights into its significance in hematopoiesis and related physiological processes. ERMAP Protein, Human (HEK293, His) is the recombinant human-derived ERMAP protein, expressed by HEK293 , with C-6*His labeled tag.
- Application
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Alternative Names
Erythroid Membrane-Associated Protein; hERMAP; Radin Blood Group Antigen; Scianna Blood Group Antigen; ERMAP; RD; SC
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Species
Human
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Source
HEK293
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Tag
C-6*His
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Purity
Greater than 95% as determined by SDS-PAGE.
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Uniprot
Q96PL5
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Expression Region
H30-A155
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Protein Length
Extracellular Domain
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Molecular Weight
16-17 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ERMAP (ER-MAPPED) is a crucial protein involved in the regulation of immune responses and plays a significant role in cell adhesion and signaling. The study of ERMAP protein has emerged from the need to understand its function in various biological processes, including immune cell development and tissue homeostasis. Research has revealed that ERMAP is expressed in several tissues, particularly in the immune system, highlighting its importance in modulating T-cell interactions and responses. The protein's unique structure and the presence of specific domains suggest its involvement in binding interactions that facilitate cell communication. The dissection of ERMAP’s molecular pathways has potential implications for therapeutic strategies, particularly in autoimmune diseases and cancer, where immune evasion or dysregulation occurs. Additionally, the exploration of ERMAP as a possible biomarker provides insights into its role in disease progression and prognostic evaluations. As research continues to uncover the complexities of ERMAP's interactions and functions, it presents exciting opportunities for advancements in immunology and the development of targeted therapies. Understanding ERMAP's role at the molecular level could pave the way for innovative treatments that modulate immune responses and improve patient outcomes.
