Analytical Data
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基因名
BAFF/TNFSF13B
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简介
BAFF/TNFSF13B protein is a cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA, forming a key ligand-receptor pathway together with TNFSF13/APRIL. These interactions play a crucial role in stimulating B-cell and T-cell function and regulating humoral immunity. BAFF/TNFSF13B Protein, Human (His-SUMO) is the recombinant human-derived BAFF/TNFSF13B protein, expressed by E. coli , with N-SUMO, N-6*His labeled tag.
- Application
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别名
BAFF; BLyS; CD257; TNFSF13B; TNFSF20; DTL; TALL1; TALL-1delta BAFF; TALL1Delta4 BAFF; THANK; ZTNF4; TALL-1
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种属
Human
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表达系统
E. coli
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标签
N-SUMO;N-6*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9Y275-1
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表达区间
Q68-L285
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氨基酸序列
QVAALQGDLASLRAELQGHHAEKLPAGAGAPKAGLEEAPAVTAGLKIFEPPAPGEGNSSQNSRNKRAVQGPEETVTQDCLQLIADSETPTIQKGSYTFVPWLLSFKRGSALEEKENKILVKETGYFFIYGQVLYTDKTYAMGHLIQRKKVHVFGDELSLVTLFRCIQNMPETLPNNSCYSAGIAKLEEGDELQLAIPRENAQISLDGDVTFFGALKLL
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蛋白长度
Extracellular Domain
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分子量
35 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
BAFF (B-cell activating factor), also known as TNFSF13B, is a critical cytokine belonging to the tumor necrosis factor (TNF) superfamily that plays a vital role in B-cell development, activation, and survival. Dysregulation of BAFF levels has been implicated in various autoimmune diseases, such as systemic lupus erythematosus (SLE) and rheumatoid arthritis, as well as in certain B-cell malignancies. Understanding the structure and function of BAFF is essential for developing targeted therapies aimed at modulating immune responses. Research on recombinant BAFF proteins has gained momentum as these proteins can facilitate the investigation of BAFF's biological activities and mechanisms of action. Additionally, recombinant BAFF can be used as a tool for in vitro assays to explore B-cell signaling pathways and as a potential therapeutic agent to enhance or inhibit B-cell responses in various clinical settings. The generation of well-characterized recombinant BAFF proteins is pivotal for elucidating the cytokine's role in the immune system and for advancing novel treatments for B-cell-related disorders. Recent studies have focused on the production, purification, and functional characterization of these proteins, paving the way for better understanding of their implications in health and disease.
