Analytical Data
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Gene name
GNAL
- Application
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Alternative Names
Adenylate cyclase stimulating G alpha protein; olfactory type; Adenylate cyclase-stimulating G alpha protein; DYT25; G alpha olf; Gnal; GNAL_HUMAN; Guanine nucleotide binding protein (G protein); alpha activating activity polypeptide; olfactory type
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P38405
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Expression Region
1-381aa
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AA Sequence
MGCLGGNSKT TEDQGVDEKE RREANKKIEK QLQKERLAYK ATHRLLLLGA GESGKSTIVK QMRILHVNGF NPEEKKQKIL DIRKNVKDAI VTIVSAMSTI IPPVPLANPE NQFRSDYIKS IAPITDFEYS QEFFDHVKKL WDDEGVKACF ERSNEYQLID CAQYFLERID SVSLVDYTPT DQDLLRCRVL TSGIFETRFQ VDKVNFHMFD VGGQRDERRK WIQCFNDVTA IIYVAACSSY NMVIREDNNT NRLRESLDLF ESIWNNRWLR TISIILFLNK QDMLAEKVLA GKSKIEDYFP EYANYTVPED ATPDAGEDPK VTRAKFFIRD LFLRISTATG DGKHYCYPHF TCAVDTENIR RVFNDCRDII QRMHLKQYEL L
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Molecular Weight
44.3 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GNAL (Guanosine Nucleotide-Binding Protein, Alpha-L) is a member of the G-protein family that plays a crucial role in various cellular signaling pathways, primarily those associated with neuronal function and neurotransmitter signaling. Recent studies have indicated that GNAL is involved in modulating dopaminergic signaling, which is integral to several physiological processes including mood regulation, movement, and reward pathways. Its dysfunction has been linked to several neurological disorders, including Parkinson’s disease and schizophrenia, making it a significant focus of research in neurobiology and pharmacology. The recombinant production of GNAL protein is essential for understanding its structure, function, and interactions with other signaling molecules. This research involves expressing GNAL in suitable host systems, such as bacteria or mammalian cells, to obtain a sufficient quantity of the protein for biochemical analyses. Characterizing GNAL through biophysical techniques and functional assays will enable researchers to unravel its specific roles in neuronal signaling and its contribution to pathophysiological conditions. This knowledge can ultimately lead to the identification of novel therapeutic targets for diseases associated with GNAL dysregulation. Thus, the study of GNAL and its recombinant forms is not only pivotal for elucidating fundamental biological mechanisms but also holds potential for addressing therapeutic challenges in treating neurological disorders.
