Analytical Data
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Gene name
GABRG1
- Application
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Alternative Names
GABRG1; Gamma-aminobutyric acid receptor subunit gamma-1; GABA(A) receptor subunit gamma-1
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8N1C3
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Expression Region
1-465aa
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AA Sequence
MGPLKAFLFSPFLLRSQSRGVRLVFLLLTLHLGNCVDKADDEDDEDLTVNKTWVLAPKIHEGDITQILNSLLQGYDNKLRPDIGVRPTVIETDVYVNSIGPVDPINMEYTIDIIFAQTWFDSRLKFNSTMKVLMLNSNMVGKIWIPDTFFRNSRKSDAHWITTPNRLLRIWNDGRVLYTLRLTINAECYLQLHNFPMDEHSCPLEFSSYGYPKNEIEYKWKKPSVEVADPKYWRLYQFAFVGLRNSTEITHTISGDYVIMTIFFDLSRRMGYFTIQTYIPCILTVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFAALMEYGTLHYFTSNQKGKTATKDRKLKNKASMTPGLHPGSTLIPMNNISVPQEDDYEYQCLEGKDCASFFCCFEDCRTGSWREGRIHIRIAKIDSYSRIFFPTAFALFNLVYWVGYLYL
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Molecular Weight
80.1 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
GABRG1, a gene encoding the gamma-aminobutyric acid type A receptor subunit 1 (GABARγ1), plays a crucial role in the functioning of the central nervous system by forming part of inhibitory neurotransmitter receptors that mediate synaptic transmission. Dysfunction in GABRG1 has been implicated in various neurological disorders, including epilepsy, anxiety, and schizophrenia, underscoring its importance in maintaining neural homeostasis. The study of GABRG1 recombinant proteins has surged in recent years, driven by the need to better understand the molecular mechanisms underlying these disorders and the potential for therapeutic interventions. Researchers utilize recombinant GABRG1 proteins to investigate receptor assembly, pharmacological properties, and interactions with other signaling molecules. Furthermore, these proteins serve as valuable tools in drug discovery, enabling the screening of compounds that modulate receptor activity and could lead to novel treatments. The exploration of GABRG1 also extends to potential genetic therapies or interventions aimed at correcting receptor function in affected individuals. Given its central role in inhibitory signaling pathways, GABRG1 research not only illuminates basic neurobiology but also holds promise for clinical applications, emphasizing the need for ongoing investigations into its structure and function.
