Analytical Data
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Gene name
G6PC2
- Application
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Alternative Names
G6PC2; IGRPGlucose-6-phosphatase 2; G-6-Pase 2; G6Pase 2; EC 3.1.3.9; Islet-specific glucose-6-phosphatase catalytic subunit-related protein
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9NQR9
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Expression Region
1-355aa
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AA Sequence
MDFLHRNGVLIIQHLQKDYRAYYTFLNFMSNVGDPRNIFFIYFPLCFQFNQTVGTKMIWVAVIGDWLNLIFKWILFGHRPYWWVQETQIYPNHSSPCLEQFPTTCETGPGSPSGHAMGASCVWYVMVTAALSHTVCGMDKFSITLHRLTWSFLWSVFWLIQISVCISRVFIATHFPHQVILGVIGGMLVAEAFEHTPGIQTASLGTYLKTNLFLFLFAVGFYLLLRVLNIDLLWSVPIAKKWCANPDWIHIDTTPFAGLVRNLGVLFGLGFAINSEMFLLSCRGGNNYTLSFRLLCALTSLTILQLYHFLQIPTHEEHLFYVLSFCKSASIPLTVVAFIPYSVHMLMKQSGKKSQ
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Molecular Weight
40.5 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
G6PC2, or Glucose-6-phosphatase catalytic subunit 2, is a crucial enzyme implicated in glucose homeostasis and is predominantly expressed in pancreatic beta cells. Its primary function involves hydrolyzing glucose-6-phosphate to glucose, thereby playing a significant role in glucose release into the bloodstream. Dysregulation of G6PC2 has been linked to various metabolic disorders, including type 2 diabetes mellitus (T2DM), making it a target of interest for research. Understanding the molecular mechanisms that regulate G6PC2 expression and activity can provide insights into beta-cell function and the pathophysiology of diabetes. Recent studies have suggested that genetic variations in the G6PC2 gene may influence the risk of developing T2DM, highlighting its potential as a biomarker for susceptibility to this condition. Furthermore, G6PC2 has been explored as a therapeutic target, with the aim of manipulating its activity to enhance insulin secretion and improve glycemic control. The development of recombinant G6PC2 proteins allows for detailed biochemical studies, facilitating the exploration of its enzymatic properties and interaction with regulatory pathways. As such, research on G6PC2 is at the forefront of diabetes metabolism studies, providing promising avenues for novel interventions in glucose regulation and diabetes management.
