Analytical Data
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Gene name
FYCO1
- Application
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Alternative Names
CATC2; CTRCT18; DKFZp779K1152; FLJ13335; FYCO1; FYCO1_HUMAN; FYVE and coiled coil domain containing 1; FYVE and coiled coil domain containing protein 1; FYVE and coiled-coil domain-containing protein 1; MGC126517; MGC126519
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9BQS8
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Expression Region
1-255aa
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AA Sequence
MNTKVTSDWYYARSPFLQPKLSSDIVGQLYELTEVQFDLASRGFDLDAAWPTFARRTLTTGSSAYLWKPPSRSSSMSSLVSSYLQTQEMVSNFDLNSPLNNEALEGFDEMRLELDQLEVREKQLQERMQQLDRENQELRAAVSQQGEQLQTERERGRTAAEDNVRLTCLVAELQKQWEVTQATQNTVKELQTCLQALELGAAEKEEDYHTALRRLESMLQPLAQELEATRDSLDKKNQHLASFPGWLAMALHVGD
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Molecular Weight
53.79 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
FYCO1 (FYVE and coiled-coil domain-containing protein 1) is an essential protein involved in intracellular trafficking, particularly in the transport of autophagosomes and lysosomes within cells. It plays a crucial role in the regulation of autophagy and lysosomal function, which are vital for maintaining cellular homeostasis and resisting various diseases. Dysfunction of FYCO1 has been implicated in several pathological conditions, including neurodegenerative diseases, cancer, and infections. Recent studies have highlighted its importance in the process of autophagic flux, where it interacts with various lipid membranes and cytoskeletal elements, facilitating the movement of organelles along microtubules. Additionally, FYCO1 is known to bind to LC3, a protein associated with autophagic vesicles, thus linking the autophagic machinery to the cytoskeletal transport system. The exploration of FYCO1 as a recombinant protein provides valuable insights into its structure and function, allowing researchers to investigate its role in cellular processes more accurately. Understanding the molecular mechanisms governing FYCO1's activity can potentially reveal new therapeutic targets for diseases related to impaired autophagy and intracellular trafficking. As such, FYCO1 has emerged as a promising biomarker and therapeutic target in the context of autophagy-related disorders, fueling ongoing research within the fields of cell biology and medicine.
