Analytical Data
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Gene name
EGR2
- Application
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Alternative Names
EGR2；KROX20；E3 SUMO-Protein ligase EGR2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P11161
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Expression Region
1-476aa
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AA Sequence
MMTAKAVDKI PVTLSGFVHQ LSDNIYPVED LAATSVTIFP NAELGGPFDQ MNGVAGDGMI NIDMTGEKRS LDLPYPSSFA PVSAPRNQTF TYMGKFSIDP QYPGASCYPE GIINIVSAGI LQGVTSPAST TASSSVTSAS PNPLATGPLG VCTMSQTQPD LDHLYSPPPP PPPYSGCAGD LYQDPSAFLS AATTSTSSSL AYPPPPSYPS PKPATDPGLF PMIPDYPGFF PSQCQRDLHG TAGPDRKPFP CPLDTLRVPP PLTPLSTIRN FTLGGPSAGV TGPGASGGSE GPRLPGSSSA AAAAAAAAAY NPHHLPLRPI LRPRKYPNRP SKTPVHERPY PCPAEGCDRR FSRSDELTRH IRIHTGHKPF QCRICMRNFS RSDHLTTHIR THTGEKPFAC DYCGRKFARS DERKRHTKIH LRQKERKSSA PSASVPAPST ASCSGGVQPG GTLCSSNSSS LGGGPLAPCS SRTRTP
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
EGR2 (Early Growth Response 2) is a zinc finger transcription factor that plays a crucial role in various biological processes, including T cell differentiation, neuronal development, and cellular response to stress. Research into recombinant EGR2 protein has gained significant attention due to its potential implications in understanding autoimmune diseases and neurodegenerative disorders. EGR2 is involved in the regulation of genes associated with these conditions, making it a key player in the immune response and neuronal signaling pathways. Studies have shown that altered EGR2 expression levels can lead to dysregulation of immune responses and contribute to disease pathogenesis, such as in multiple sclerosis and rheumatoid arthritis. The production of recombinant EGR2 protein allows scientists to investigate its functional properties, protein interactions, and role in gene regulation in detail. This understanding can pave the way for developing targeted therapies that modulate EGR2 activity, aiming to restore normal immune function or promote neuroprotection. Furthermore, the ability to manipulate EGR2 expression in various cellular models facilitates the exploration of its involvement in signal transduction pathways and the mechanism by which it influences cell fate decisions. Overall, recombinant EGR2 protein serves as an essential tool for elucidating the molecular mechanisms underlying its diverse biological roles and advancing therapeutic strategies against relevant diseases.
