Analytical Data
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Gene name
FMNL3
- Application
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Alternative Names
FMNL3; FHOD3; FRL2; KIAA2014; WBP3; Formin-like protein 3; Formin homology 2 domain-containing protein 3; WW domain-binding protein 3; WBP-3
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8IVF7
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Expression Region
1-347aa
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AA Sequence
MRFLPTEAEVKLLRQYERERQPLEELAAEDRFMLLFSKVERLTQRMAGMAFLGNFQDNLQMLTPQLNAIIAASASVKSSQKLKQMLEIILALGNYMNSSKRGAVYGFKLQSLDLLLDTKSTDRKMTLLHFIALTVKEKYPDLANFWHELHFVEKAAAVSLENVLLDVKELGRGMELIRRECSIHDNSVLRNFLSTNEGKLDKLQRDAKTAEEAYNAVVRYFGESPKTTPPSVFFPVFVRFIRSYKEAEQENEARKKQEEVMREKQLAQEAKKLDAKTPSQRNKWQQQELIAELRRRQAKEHRPVYEGKDGTIEDIITVLKSVPFTARTAKRGSRFFCDAAHHDESNC
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Molecular Weight
66.5 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
FMNL3 (Formin-like protein 3) is a member of the formin family of proteins, known for their role in the regulation of actin cytoskeleton dynamics. These proteins are critical in various cellular processes, including cell migration, division, and organization of cellular structures. FMNL3 is particularly interesting due to its involvement in significant biological functions such as cell motility and the formation of cellular protrusions, which are essential in development and immune response. Recent studies have suggested that FMNL3 is implicated in various pathological conditions, including cancer metastasis and neuronal development, highlighting the importance of understanding its molecular mechanisms. Research on FMNL3 often focuses on the production of recombinant FMNL3 proteins, which are utilized to elucidate its structure-function relationships and interaction with other cellular components. By expressing FMNL3 as a recombinant protein, researchers can investigate its biological activity, regulatory pathways, and potential as a therapeutic target. Advances in protein engineering and purification techniques have enabled the comprehensive study of FMNL3, paving the way for novel insights into its role in health and disease. This research not only deepens our understanding of formins but also opens avenues for targeted therapies aimed at conditions where FMNL3 activity is dysregulated. As a result, the study of recombinant FMNL3 proteins holds promise for the development of innovative treatment strategies in oncology and regenerative medicine.
