Analytical Data
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基因名
OCTN1
- Application
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别名
OCTN1；ETT；OCTN1；UT2H；Solute carrier family 22 member 4
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9H015
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表达区间
1-551aa
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氨基酸序列
MRDYDEVIAFLGEWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTPEHRCRVPDAANLSSAWRNNSVPLRLRDGREVPHSCSRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFSQDVYLSTVVTEWNLVCEDNWKVPLTTSLFFVGVLLGSFVSGQLSDRFGRKNVLFATMAVQTGFSFLQIFSISWEMFTVLFVIVGMGQISNYVVAFILGTEILGKSVRIIFSTLGVCTFFAVGYMLLPLFAYFIRDWRMLLLALTVPGVLCVPLWWFIPESPRWLISQRRFREAEDIIQKAAKMNNIAVPAVIFDSVEELNPLKQQKAFILDLFRTRNIAIMTIMSLLLWMLTSVGYFALSLDAPNLHGDAYLNCFLSALIEIPAYITAWLLLRTLPRRYIIAAVLFWGGGVLLFIQLVPVDYYFLSIGLVMLGKFGITSAFSMLYVFTAELYPTLVRNMAVGVTSTASRVGSIIAPYFVYLGAYNRMLPYIVMGSLTVLIGILTLFFPESLGMTLPETLEQMQKVKWFRSGKKTRDSMETEENPKVLITAF
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分子量
62.1 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
OCTN1 (Organic Cation Transporter Novel 1) is a member of the SLC22 family of solute carrier transporters, primarily involved in the transport of organic cations and zwitterions across cellular membranes. This protein has garnered significant research interest due to its role in drug disposition, nutrient transport, and potential involvement in various physiological processes. Initially identified in humans, OCTN1 is expressed in various tissues, including the kidney, brain, and intestine, indicating its importance in systemic metabolism and homeostasis. Notably, mutations or dysfunctions in the OCTN1 gene have been associated with disorders, including primary carnitine deficiency, emphasizing its relevance in clinical settings. The study of recombinant OCTN1 protein allows researchers to explore its transport mechanisms, substrate specificity, and interactions with both endogenous compounds and therapeutic agents. Furthermore, investigating this transporter can aid in understanding drug-drug interactions and individual variability in drug response, thus contributing to the fields of pharmacogenomics and personalized medicine. The production and characterization of OCTN1 recombinant protein provides a critical platform for advancing knowledge about its biological functions and therapeutic implications, ultimately aiming to develop strategies for better management of diseases linked to its dysregulation.
