Analytical Data
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Gene name
UNC84A
- Application
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Alternative Names
Protein unc-84 homolog A; Sad1 and UNC84 domain containing 1; Sad1/unc 84 Protein like 1; Sad1/unc-84 Protein-like 1; Sun domain-containing Protein 1; Sun1; SUN1_HUMAN; UNC 84 homolog A (C elegans); UNC 84A; UNC84 A; UNC84; UNC84 homolog A (C elegans); UNC84A
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O94901
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Expression Region
1-257 aa
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AA Sequence
MDFSRLHMYSPPQCVPENTGYTYALSSSYSSDALDFETEHKLDPVFDSPRMSRRSLRLATTACTLGDGEAVGADSGTSSAVSLKNRAARTTKQRRSTNKSAFSINHVSRQVTSSGVSHGGTVSLQDAVTRRPPVLDESWIREQTTVDHFWGLDDDGDLKGGSKAAIQGNGDVGAAAATAHNGFSCSNCSMLSERKDVLTAHPAPPGPVSRVYSRDRNQKCKSQSFKTQKKVCFPNLIFPFCKSQCLHYLSWRLKIIP
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Molecular Weight
54.01 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
UNC84A (UAE) is a significant protein that plays a crucial role in cellular processes, particularly in the context of nuclear envelope organization and function. Initially identified in *Caenorhabditis elegans*, UNC84A is part of a small family of proteins characterized by their interaction with the nuclear envelope and potential involvement in the transport of nuclear components. Its homologs have been found across various species, suggesting evolutionary conservation and importance in cellular mechanics. Research has indicated that UNC84A is essential for maintaining the integrity of the nuclear envelope, and its dysfunction is linked to various diseases, including certain forms of muscular dystrophy. The study of UNC84A recombinant protein has gained momentum as scientists aim to elucidate its structural properties, interaction partners, and mechanistic roles within the cell. Understanding UNC84A's function could provide insights into the pathogenesis of nuclear envelope-related disorders and pave the way for potential therapeutic strategies. Furthermore, the development of UNC84A recombinant protein offers opportunities for high-throughput screening and structural biology applications, allowing for a better comprehension of its role in health and disease. As researchers delve deeper into the characterization of UNC84A, it is anticipated that this protein will reveal critical aspects of nuclear biology and contribute significantly to our understanding of cellular homeostasis and pathology.
