Analytical Data
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基因名
TKL1
- Application
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别名
TKL1；Serine/threonine-Protein kinase tousled-like 1
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种属
E.coli
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q12630
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表达区间
1-679aa
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氨基酸序列
MSQYTDIDRLAVSTIRLLAVDQVSAANSGHPGAPLGLAPAAHVIWKQMRLNPKNPEWINRDRFVLSNGHACALLYSLLHLFGYDMSIEDLKHFRHLGSKTPGHPEFELPGVEVTTGPLGQGISNAVGMAIAQANFAATYNKPDYELSDSYTYVFLGDGCLQEGVSSEASSLAGHLRLKNLIAFYDDNQITIDGNINVSFDEDVSKRYEAYGWEVLHVENGNDDLDAISKALEQAKLSDRPTLIKLTTTIGFGSLNAGSHSVHGAPLKADDVKQLKVKFGFNPEESFVVPQEVYDLYNKSTIEPGIEANKQWDALLDAYVGQFPELGAEVKRRLAGEFPEGWESKLPTYTPEDSAVASRKLSEIVLDNVFDTLPELLGGSADLTPSNLTRSKGAVDFQPPITGLGDYSGRYIRYGVREHGMGAIMNGISAFGANYRPYGGTFLNFVSYASGAVRLSALSGHPVIWVATHDSIGLGEDGPTHQPIETLAHFRAIPNLQVWRPADGNEVTAAYKVALTNKHTPAIIALSRQNLPQLQGSSVEKAVKGGYILQDVDQPDLAIVSTGSEVGIAVEAAKVLAEKNIKARIVSLPDFHSFGQQSKEYQLSVFPDGVPILSVEVLATSGWSKYAHQSFGLDRFGASGKGPAVYEKFEFTPQGIATRAEKTVEFYKGKQVISPLNTAF
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The TKL1 recombinant protein has garnered significant attention in the field of molecular biology and biotechnology due to its potential applications in various therapeutic and industrial processes. TKL1, or transketolase-like 1, is an enzyme involved in the pentose phosphate pathway, which plays a crucial role in cellular metabolism by facilitating the conversion of sugars and the maintenance of redox balance. Its unique catalytic properties and ability to regulate metabolic flux have led to research focusing on harnessing TKL1 for both metabolic engineering and biopharmaceutical production. Additionally, studies have suggested TKL1's involvement in cellular stress responses and its implications in diseases, particularly in cancer metabolism where altered metabolic pathways can influence tumor growth and survival. Furthermore, the production of recombinant TKL1 in heterologous systems allows for detailed structural and functional analyses, enabling scientists to explore its enzymatic mechanisms and potential targets for drug design. As interest in precision medicine and targeted therapies rises, understanding TKL1's role in metabolic pathways could open avenues for novel therapeutic strategies and innovative biotechnological applications. Consequently, ongoing research aims to elucidate its functional dynamics, optimize expression systems, and evaluate its efficacy in various applications, making TKL1 a promising candidate for future studies in metabolic regulation and therapeutic development.
