Analytical Data
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基因名
ZSWIM2
- Application
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别名
E3 ubiquitin-protein ligase ZSWIM2. EC:2.3.2.27. MEKK1-related protein X. MEX. RING-type E3 ubiquitin transferase ZSWIM2. ZZ-type zinc finger-containing protein 2. Zinc finger SWIM domain-containing protein 2
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8NEG5
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表达区间
1-633 aa
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氨基酸序列
MLRRGYKASERRRHLSERLSWHQDQALSSSIYLLREMGPTGFLLREEEPEYMDFRVFLGNPHVCNCSTFPKGGELCKHICWVLLKKFKLPRNHESALQLGLGEREISDLLRGIHRVQTPQPGTNDENEHVEEDGYIKQKEIDSEDICSICQELLLEKKLPVTFCRFGCGNSIHIKCMKILANYQSTSNTSMLKCPLCRKEFAPLKLILEEFKNSSKLVAAAEKERLDKHLGIPCNNCKQFPIEGKCYKCTECIEYHLCQECFDSCCHLSHTFTFREKRNQKWRSLEKRADEVVKYIDTKNEIEEKMSHFQEKQGQVYTPKHIVRSLPLQLITKNSKLLAPGYQCLLCLKAFHLGQHTRLLPCTHKFHRKCIDNWLFHKCNSCPIDGQVIYNPLTWKNSAVNGQAHQSVSNRDIIHLSKQKEPDLFIPGTGLVLKQNRLGILPSIPQCNFDELNTPQSPKDAYENTTIDNLCSIKLDNSNSKKLTYDYKISQHFPRYLQDLPTVSFGKIPSQTLLPPIVHKNIVCPTAMESPCISGKFHTSLSRMTKGCKCNNHNLKKTPATKIREDNKRSTLLPEDFNLIVNWSTAKLSLSKRYSNCMGEITRKCSHLSRQPVSHSVNTKSTELSLIIEGVQL
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分子量
99.1 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ZSWIM2 is a protein belonging to the ZSWIM family, characterized by the presence of a C-terminal SWIM (SWI2/SNF2 and MuDR) domain, which plays a crucial role in various biological processes, including DNA repair, transcription regulation, and cellular response to stress. Recent research highlights the significance of ZSWIM2 in the context of cancer biology and cellular development. It has been implicated in the regulation of gene expression and protein interactions that are essential for maintaining genomic stability. Studies have demonstrated that mutations or dysregulation of ZSWIM2 can contribute to tumorigenesis and may serve as potential biomarkers for cancer diagnosis and prognosis. Additionally, ZSWIM2 has been shown to interact with other critical proteins involved in chromatin remodeling and repair mechanisms, suggesting a complex network of functional relationships within cellular processes. Understanding the structure and function of ZSWIM2 through recombinant protein studies may provide valuable insights into its mechanistic roles and therapeutic potential, leading to novel strategies in combating diseases linked to its dysregulation. Overall, the exploration of ZSWIM2 as a recombinant protein represents a promising avenue for advancing our knowledge of its contributions to cell biology and disease pathology.
