Analytical Data
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基因名
ULK3
- Application
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别名
DKFZP434C131; FLJ90566; Serine/threonine-Protein kinase ULK3; Ulk3; ULK3_HUMAN; unc 51 like kinase 3 (C. elegans); Unc-51-like kinase 3
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q6PHR2
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表达区间
1-472 aa
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氨基酸序列
MAGPGWGPPR LDGFILTERL GSGTYATVYK AYAKKDTREV VAIKCVAKKS LNKASVENLL TEIEILKGIR HPHIVQLKDF QWDSDNIYLI MEFCAGGDLS RFIHTRRILP EKVARVFMQQ LASALQFLHE RNISHLDLKP QNILLSSLEK PHLKLADFGF AQHMSPWDEK HVLRGSPLYM APEMVCQRQY DARVDLWSMG VILYEALFGQ PPFASRSFSE LEEKIRSNRV IELPLRPLLS RDCRDLLQRL LERDPSRRIS FQDFFAHPWV DLEHMPSGES LGRATALVVQ AVKKDQEGDS AAALSLYCKA LDFFVPALHY EVDAQRKEAI KAKVGQYVSR AEELKAIVSS SNQALLRQGT SARDLLREMA RDKPRLLAAL EVASAAMAKE EAAGGEQDAL DLYQHSLGEL LLLLAAEPPG RRRELLHTEV QNLMARAEYL KEQVKMRESR WEADTLDKEG LSESVRSSCT LQ
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分子量
53.4 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ULK3 (Unc-51 Like Autophagy Activating Kinase 3) is a serine/threonine kinase that plays a crucial role in the regulation of autophagy, a cellular process involved in degrading and recycling cellular components. The study of ULK3 has gained significant attention due to its implications in various physiological and pathological contexts, including cancer, neurodegenerative diseases, and metabolic disorders. As a member of the ULK family, ULK3 is activated in response to cellular stressors and nutrient availability, thus serving as an important regulator in the autophagy pathway. Understanding the molecular mechanisms underlying ULK3’s function may unveil new therapeutic targets for diseases characterized by dysregulated autophagy. Recent research has focused on the purification and characterization of ULK3 recombinant protein, which provides a valuable tool for studying its enzymatic activity, substrate specificity, and interaction with other proteins within the autophagy machinery. The generation of ULK3 recombinant protein allows researchers to investigate its role in autophagy modulation and explore potential avenues for drug development aimed at enhancing or inhibiting autophagy in various disease contexts. Moreover, studying the post-translational modifications and regulatory mechanisms of ULK3 could yield insights into how cellular signaling pathways influence autophagy and how these processes are altered in diseases. Overall, research on ULK3 recombinant protein is expected to contribute significantly to our understanding of autophagy dynamics and its implications for human health.
