Analytical Data
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Gene name
UHRF2
- Application
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Alternative Names
DKFZp434B0920; DKFZp686G0837; E3 ubiquitin-Protein ligase UHRF2; MGC33463; Np95 like RING finger Protein; Np95-like ring finger Protein; Np95/ICBP90 like RING finger Protein; Np95/ICBP90-like RING finger Protein; Nuclear Protein 97; Nuclear zinc finger Protein Np97; RING finger Protein 107; RNF 107; RP11-472F14.2; Ubiquitin like containing PHD and RING finger domains Protein 2; Ubiquitin-like PHD and RING finger domain-containing Protein 2; Ubiquitin-like-containing PHD and RING finger domains Protein 2; Uhrf2; UHRF2_HUMAN; URF 2
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q96PU4
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Expression Region
1-503 aa
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AA Sequence
MWIQVRTIDGSKTCTIEDVSRKATIEELRERVWALFDVRPECQRLFYRGKQLENGYTLFDYDVGLNDIIQLLVRPDPDHLPGTSTQIEAKPCSNSPPKVKKAPRVGPSNQPSTSARARLIDPGFGIYKVNELVDARDVGLGAWFEAHIHSVTRASDGQSRGKTPLKNGSSCKRTNGNIKHKSKENTNKLDSVPSTSNSDCVAADEDVIYHIQYDEYPESGTLEMNVKDLRPRARTILKWNELNVGDVVMVNYNVESPGQRGFWFDAEITTLKTISRTKKELRVKIFMGGSEGTLNDCKIISVDEIFKIERPGAHPLSFADGKFLRRNDTECDLCGGDPEKKCHSCSCRVCGGKHEPNMQLLCDECNVAYHIYCLNPPLDKVPEEEYWYCPSCKTDSSEVVKAGERLKMSKKKAKMQSASTESRRDWGRGMACVGRTRECTIVPSNHYGPIPGIPVGSTWRFRVQVSEAGVHRPHVGGIHGRSNDGAYSLVLAGGFADEVLTEL
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Molecular Weight
82.5 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
UHRF2, or Ubiquitin-like with PHD and RING finger domains 2, is a protein that has garnered attention in recent years due to its pivotal role in epigenetic regulation, particularly in maintaining DNA methylation and histone modification patterns. It is a member of the UHRF family, which is known to be involved in the recognition and binding of specific histone marks, as well as in the recruitment of DNA methyltransferases during DNA replication. Research indicates that UHRF2 is critical for the maintenance of genomic stability and expression of tumor suppressor genes, making it a target of interest in cancer biology. The study of UHRF2 is also significant in understanding the molecular mechanisms underlying various diseases, including cancer, where dysregulation of epigenetic modifications can lead to aberrant gene expression and tumorigenesis. Current investigations into the recombinant expression of UHRF2 have focused on elucidating its structural, functional, and interaction properties, which can provide insights into its role in the pathogenesis of diseases and potential therapeutic strategies. Given its essential functions, the recombinant UHRF2 protein serves as a valuable tool for studying its biological activities and for developing inhibitors that could restore normal epigenetic regulation in affected cells. Overall, the research on UHRF2 and its recombinant protein not only enhances our understanding of epigenetic regulation but also opens new avenues for targeted therapies in cancer and other related diseases.
