Analytical Data
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基因名
LPHN3
- Application
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别名
LPHN3；KIAA0768；LEC3；LPHN3；Adhesion G Protein-coupled receptor L3
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9HAR2
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表达区间
全长
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氨基酸序列
full
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
LPHN3 (Latrophilin 3) is a member of the latrophilin subfamily of G protein-coupled receptors, which are known for their roles in cell adhesion and signaling processes critical for synaptic development and maintenance. Research into LPHN3 has gained interest due to its association with neurodevelopmental disorders, particularly its potential links to autism spectrum disorders (ASD) and attention-deficit/hyperactivity disorder (ADHD). This receptor is believed to mediate interactions between neurons and other cell types, influencing synapse formation and stabilization. Recent studies highlight its function in modulating neurotransmitter release and dendritic spine formation. Given that genetic variations in LPHN3 have been linked to increased vulnerability to ASD, understanding its molecular mechanisms presents a promising avenue for therapeutic interventions. The production of recombinant LPHN3 proteins allows for deeper investigation into its structure-function relationship, facilitating studies that explore its receptor dynamics, ligand interactions, and role in synaptic plasticity. These insights could ultimately contribute to the development of targeted treatments for neurodevelopmental conditions associated with dysregulation of this crucial receptor.
