Analytical Data
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基因名
PRDM1
- Application
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别名
PRDM1；BLIMP1；PR domain zinc finger Protein 1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O75626-2
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表达区间
1-109aa
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氨基酸序列
MKMDMEDADMTLWTEAEFEEKCTYIVNDHPWDSGADGGTSVQAEASLPRN LLFKYATNSEEVIGVMSKEYIPKGTRFGPLIGEIYTNDTVPKNANRKYFW RIYSRGELH
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分子量
38 kD
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PRDM1, also known as Blimp-1, is a transcription factor critically involved in the regulation of immune responses and cell differentiation. It plays a vital role in various biological processes, including B and T cell differentiation, development of plasma cells, and the regulation of the immune system. Research has shown that PRDM1 is essential for the formation of plasma cells that produce antibodies, thus contributing to humoral immunity. Its dysfunction is linked to several pathologies, including autoimmunity and certain types of cancer, making it an important target for therapeutic intervention. Additionally, PRDM1's role in suppressing oncogenic pathways highlights its potential as a tumor suppressor, especially in hematological malignancies. The study of recombinantly expressed PRDM1 protein allows researchers to better understand its functional mechanisms, post-translational modifications, and interactions with other proteins. This knowledge can further our understanding of immune regulation and open up new avenues for developing treatments for immune-related diseases and cancers.
