Analytical Data
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基因名
UBQLN3
- Application
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别名
TUP1; Ubiquilin 3; Ubiquilin-3; UBQL3_HUMAN; UBQLN3
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9H347
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表达区间
1-655 aa
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氨基酸序列
MAKGGEALPQ GSPAPVQDPH LIKVTVKTPK DKEDFSVTDT CTIQQLKEEI SQRFKAHPDQ LVLIFAGKIL KDPDSLAQCG VRDGLTVHLV IKRQHRAMGN ECPAASVPTQ GPSPGSLPQP SSIYPADGPP AFSLGLLTGL SRLGLAYRGF PDQPSSLMRQ HVSVPEFVTQ LIDDPFIPGL LSNTGLVRQL VLDNPHMQQL IQHNPEIGHI LNNPEIMRQT LEFLRNPAMM QEMIRSQDRV LSNLESIPGG YNVLCTMYTD IMDPMLNAVQ EQFGGNPFAT ATTDNATTTT SQPSRMENCD PLPNPWTSTH GGSGSRQGRQ DGDQDAPDIR NRFPNFLGII RLYDYLQQLH ENPQSLGTYL QGTASALSQS QEPPPSVNRV PPSSPSSQEP GSGQPLPEES VAIKGRSSCP AFLRYPTENS TGQGGDQDGA GKSSTGHSTN LPDLVSGLGD SANRVPFAPL SFSPTAAIPG IPEPPWLPSP AYPRSLRPDG MNPAPQLQDE IQPQLPLLMH LQAAMANPRA LQALRQIEQG LQVLATEAPR LLLWFMPCLA GTGSVAGGIE SREDPLMSED PLPNPPPEVF PALDSAELGF LSPPFLHMLQ DLVSTNPQQL QPEAHFQVQL EQLRSMGFLN REANLQALIA TGGDVDAAVE KLRQS
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分子量
70.8 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
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Protein Description
UBQLN3 (Ubiquilin 3) is a member of the Ubiquilin family of proteins that plays a critical role in the regulation of protein homeostasis, linking ubiquitination and proteasomal degradation processes. Research into UBQLN3 has gained momentum due to its involvement in various cellular mechanisms, including the modulation of protein stability, trafficking, and the turnover of misfolded proteins. Dysregulation of UBQLN3 has been implicated in several neurodegenerative diseases, such as Alzheimer’s and Parkinson’s, where the accumulation of damaged proteins can lead to cellular toxicity. Moreover, UBQLN3 is believed to have a protective role in cellular stress responses, making it a potential target for therapeutic interventions. The study of UBQLN3 recombinant proteins allows for a detailed understanding of its structural and functional properties, as well as its interactions with client proteins and ubiquitin ligases. By employing techniques such as protein expression, purification, and functional assays, researchers aim to elucidate the precise mechanisms by which UBQLN3 influences proteostasis and contributes to disease pathology. This research not only contributes to the fundamental understanding of protein homeostasis but also holds promise for developing novel strategies to combat diseases associated with protein misfolding and aggregation. As UBQLN3's role expands beyond mere protein turnover, it becomes essential to map its full range of interactions and regulatory functions within the cell, paving the way for potential therapeutic avenues targeting UBQLN3 in disease contexts.
