Analytical Data
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Gene name
LRRC32
- Application
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Alternative Names
LRRC32；D11S833E；Transforming growth factor beta activator LRRC32
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q14392
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Expression Region
1-662aa
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AA Sequence
MRPQILLLLALLTLGLAAQHQDKVPCKMVDKKVSCQVLGLLQVPSVLPPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLAMATALSAGGLGPLPRVTSLDLSGNSLYSGLLERLLGEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRNSLTCISDFSLQQLRVLDLSCNSIEAFQTASQPQAEFQLTWLDLRENKLLHFPDLAALPRLIYLNLSNNLIRLPTGPPQDSKGIHAPSEGWSALPLSAPSGNASGRPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLDLSHNALETLELGARALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVSPCGGPDEPGPSGCVAFSGITSLRSLSLVDNEIELLRAGAFLHTPLTELDLSSNPGLEVATGALGGLEASLEVLALQGNGLMVLQVDLPCFICLKRLNLAENRLSHLPAWTQAVSLEVLDLRNNSFSLLPGSAMGGLETSLRRLYLQGNPLSCCGNGWLAAQLHQGRVDVDATQDLICRFSSQEEVSLSHVRPEDCEKGGLKNINLIIILTFILVSAILLTTLAACCCVRRQKFNQQYKA
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Molecular Weight
71.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
The study of LRRC32 (Leucine-Rich Repeat Containing 32), also known as GARP (Glycoprotein A repetitions predominant), has gained significant attention due to its critical role in immune regulation and its potential implications in therapeutic applications. LRRC32 is predominantly expressed on regulatory T cells (Tregs) and plays a vital role in the retention and activation of these cells within the immune system. Its primary function is to bind and sequester latent transforming growth factor-beta (TGF-β), thereby modulating immune responses and maintaining tolerance. This mechanism is particularly important in preventing autoimmune diseases and promoting tumor immunity. Researchers are investigating the potential of LRRC32 as a biomarker for various diseases, including cancer, where dysregulation of Tregs can contribute to tumor progression. The development of recombinant LRRC32 proteins offers a unique opportunity to explore its functional properties and therapeutic potential, including the enhancement of anti-tumor immunity or the modulation of autoimmune conditions. Understanding the structural and functional dynamics of LRRC32 can lead to innovative approaches in immunotherapy and the design of more effective vaccines. As studies continue to unveil the multifaceted roles of LRRC32 in immune regulation, the knowledge gained may pave the way for novel interventions targeting Treg functions and improving patient outcomes in various disease contexts.
