Analytical Data
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Gene name
UBFD1
- Application
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Alternative Names
Ubfd1; UBFD1_HUMAN; Ubiquitin domain-containing Protein UBFD1; Ubiquitin-binding Protein homolog; UBPH
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O14562
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Expression Region
1-309 aa
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AA Sequence
MAAAGAPDGM EEPGMDTEAE TVATEAPARP VNCLEAEAAA GAAAEDSGAA RGSLQPAPAQ PPGDPAAQAS VSNGEDAGGG AGRELVDLKI IWNKTKHDVK FPLDSTGSEL KQKIHSITGL PPAMQKVMYK GLVPEDKTLR EIKVTSGAKI MVVGSTINDV LAVNTPKDAA QQDAKAEENK KEPLCRQKQH RKVLDKGKPE DVMPSVKGAQ ERLPTVPLSG MYNKSGGKVR LTFKLEQDQL WIGTKERTEK LPMGSIKNVV SEPIEGHEDY HMMAFQLGPT EASYYWVYWV PTQYVDAIKD TVLGKWQYF
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Molecular Weight
33.3 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
UBFD1, or Ubiquitin-Complementation Factor D1, is a vital protein that plays a crucial role in regulating various cellular processes, including protein degradation and cell signaling. The study of UBFD1 has gained momentum due to its involvement in the ubiquitin-proteasome system, which is essential for maintaining cellular homeostasis and modulating the immune response. Recent research highlights its significance in various diseases, including cancer and neurodegenerative disorders, where dysregulation of protein degradation pathways can lead to the accumulation of misfolded proteins and subsequent cellular dysfunction. Understanding the structure and function of UBFD1 can provide insights into its specific roles in these pathological conditions and open avenues for targeted therapeutic interventions. The recombinant expression of UBFD1 allows for detailed biochemical and biophysical characterization, which is crucial for elucidating its mechanisms and interactions with other cellular components. As the landscape of protein research continues to evolve, UBFD1 represents a promising target for developing innovative treatments that harness the power of modulating protein homeostasis and restoring normal cellular function. This makes UBFD1 a focal point in both basic and translational research, with the potential for significant implications in improving clinical outcomes for various diseases.
