Analytical Data
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Gene name
NR1D2
- Application
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Alternative Names
NR1D2；Nuclear receptor subfamily 1 group D member 2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q14995
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Expression Region
1-579aa
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AA Sequence
MEVNAGGVIA YISSSSSASS PASCHSEGSE NSFQSSSSSV PSSPNSSNSD TNGNPKNGDL ANIEGILKND RIDCSMKTSK SSAPGMTKSH SGVTKFSGMV LLCKVCGDVA SGFHYGVHAC EGCKGFFRRS IQQNIQYKKC LKNENCSIMR MNRNRCQQCR FKKCLSVGMS RDAVRFGRIP KREKQRMLIE MQSAMKTMMN SQFSGHLQND TLVEHHEQTA LPAQEQLRPK PQLEQENIKS SSPPSSDFAK EEVIGMVTRA HKDTFMYNQE QQENSAESMQ PQRGERIPKN MEQYNLNHDH CGNGLSSHFP CSESQQHLNG QFKGRNIMHY PNGHAICIAN GHCMNFSNAY TQRVCDRVPI DGFSQNENKN SYLCNTGGRM HLVCPLSKSP YVDPHKSGHE IWEEFSMSFT PAVKEVVEFA KRIPGFRDLS QHDQVNLLKA GTFEVLMVRF ASLFDAKERT VTFLSGKKYS VDDLHSMGAG DLLNSMFEFS EKLNALQLSD EEMSLFTAVV LVSADRSGIE NVNSVEALQE TLIRALRTLI MKNHPNEASI FTKLLLKLPD LRSLNNMHSE ELLAFKVHP
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
NR1D2, also known as Nuclear Receptor Subfamily 1 Group D Member 2, is a transcription factor that plays a critical role in the regulation of circadian rhythms and metabolic processes. As a member of the nuclear receptor family, NR1D2 is involved in various physiological functions, including lipid metabolism, circadian regulation, and the modulation of glucose homeostasis. Its importance has been underscored by studies linking NR1D2 dysfunction to metabolic disorders such as obesity, diabetes, and dyslipidemia. The interest in NR1D2 as a research target has grown significantly due to its potential as a therapeutic intervention in treating these disorders. Advances in recombinant protein technology have enabled the production of NR1D2 in heterologous systems, facilitating detailed studies of its structure, function, and interaction with other biomolecules. Understanding the precise role of NR1D2 in metabolic regulation can provide insights into the mechanisms underlying circadian rhythm disruptions and their effects on health. Thus, research on NR1D2 recombinant proteins not only enhances the basic understanding of nuclear receptor biology but also opens avenues for developing novel therapeutic strategies aimed at metabolic diseases.
