Analytical Data
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基因名
TXNRD3NB
- Application
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别名
TXNRD3NB; TR2IT1; TXNRD3IT1; TXNRD3NT1Protein TXNRD3NB; Thioredoxin reductase 2 intronic transcript 1; Thioredoxin reductase 3 intronic transcript 1; Thioredoxin reductase 3 neighbor gene Protein; TXNRD3 neighbor gene Protein; Thioredoxin reductase 3 new transcript 1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q6F5E7
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表达区间
1-133 aa
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氨基酸序列
MRDLSERRLG QPELKAEQQM PLEPVRARLS VGLACCCSHT TAEASSLEHG DKVFGQGFPS PLEEIKRLLK ISRALQARSV PSTQEKAKCL SGEPGQPEGK GQETYPGPGK VEGKAEPAMR KDDVCPGMKC ISG
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分子量
70.6 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The TXNRD3NB protein, a member of the thioredoxin reductase family, has garnered significant interest in recent years due to its proposed role in redox regulation and cellular signaling. Thioredoxin reductases are essential enzymes that maintain the balance of reactive oxygen species (ROS) in cells, thereby influencing various biological processes, including cell proliferation, apoptosis, and stress response. TXNRD3NB, specifically, is believed to be involved in the modulation of redox environments within mitochondria and the cytoplasm, which are crucial for maintaining cellular health and function. Research has indicated that aberrations in thioredoxin reductase activity can lead to various pathologies, including cancer and neurodegenerative disorders. Consequently, the recombinant expression and purification of TXNRD3NB are of particular significance, allowing researchers to investigate its enzymatic properties, substrate specificity, and potential regulatory mechanisms. Understanding the functional roles of TXNRD3NB could provide insights into its contribution to oxidative stress and its implications in disease states. Additionally, studying this protein may open avenues for therapeutic interventions aimed at restoring redox balance and mitigating oxidative damage in cells. As a result, TXNRD3NB is a promising target for future research in redox biology and therapeutic development.
