Analytical Data
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Gene name
TXNDC3
- Application
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Alternative Names
NME8; SPTRX2; TXNDC3; Thioredoxin domain-containing Protein 3; NM23-H8; NME/NM23 family member 8; Spermatid-specific thioredoxin-2; Sptrx-2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8N427
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Expression Region
1-588 aa
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AA Sequence
MASKKREVQL QTVINNQSLW DEMLQNKGLT VIDVYQAWCG PCRAMQPLFR KLKNELNEDE ILHFAVAEAD NIVTLQPFRD KCEPVFLFSV NGKIIEKIQG ANAPLVNKKV INLIDEERKI AAGEMARPQY PEIPLVDSDS EVSEESPCES VQELYSIAII KPDAVISKKV LEIKRKITKA GFIIEAEHKT VLTEEQVVNF YSRIADQCDF EEFVSFMTSG LSYILVVSQG SKHNPPSEET EPQTDTEPNE RSEDQPEVEA QVTPGMMKNK QDSLQEYLER QHLAQLCDIE EDAANVAKFM DAFFPDFKKM KSMKLEKTLA LLRPNLFHER KDDVLRIIKD EDFKILEQRQ VVLSEKEAQA LCKEYENEDY FNKLIENMTS GPSLALVLLR DNGLQYWKQL LGPRTVEEAI EYFPESLCAQ FAMDSLPVNQ LYGSDSLETA EREIQHFFPL QSTLGLIKPH ATSEQREQIL KIVKEAGFDL TQVKKMFLTP EQIEKIYPKV TGKDFYKDLL EMLSVGPSMV MILTKWNAVA EWRRLMGPTD PEEAKLLSPD SIRAQFGISK LKNIVHGASN AYEAKEVVNR LFEDPEEN
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Molecular Weight
67.2 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
TXNDC3, or Thioredoxin Domain Containing 3, is a member of the thioredoxin family and plays a crucial role in various cellular processes, including redox regulation, cell proliferation, and apoptosis. Research has increasingly focused on TXNDC3 due to its involvement in multiple diseases, including cancer and neurodegenerative disorders. Its ability to modulate protein folding and stability underscores its potential as a therapeutic target. Additionally, the expression levels of TXNDC3 have been correlated with poor clinical outcomes in certain cancers, suggesting its role as a biomarker for disease progression. Understanding the structure and function of TXNDC3 through recombinant protein studies can elucidate its mechanisms in cellular contexts and provide insights into its potential as a drug target. Furthermore, the generation of TXNDC3 recombinant proteins allows for in-depth functional assays and structural analyses, facilitating the exploration of its interactions with other cellular components. This research is essential for developing novel therapeutic strategies aimed at modulating TXNDC3 activity in disease settings, thereby highlighting the significance of TXNDC3 as a focal point in redox biology and disease management.
