Analytical Data
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基因名
FBXO42
- Application
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别名
F box only protein 42 ; F box protein 42; F-box only protein 42; Fbx 42; FBX42 ; FBX42_HUMAN; FBXO 42; FBXO42; JFK; Just one F-box and Kelch domain-containing protein; KIAA1332
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q6P3S6
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表达区间
1-716aa
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氨基酸序列
MASSSDSEDDSFMAVDQEETVLEGTMDQDEEPHPVLEAEETRHNRSMSELPEEVLEYILSFLSPYQEHKTAALVCKQWYRLIKGVAHQCYHGFMKAVQEGNIQWESRTYPYPGTPITQRFSHSACYYDANQSMYVFGGCTQSSCNAAFNDLWRLDLNSKEWIRPLASGSYPSPKAGATLVVYKDLLVLFGGWTRPSPYPLHQPERFFDEIHTYSPSKNWWNCIVTTHGPPPMAGHSSCVIDDKMIVFGGSLGSRQMSNDVWVLDLEQWAWSKPNISGPSPHPRGGQSQIVIDDATILILGGCGGPNALFKDAWLLHMHSGPWAWQPLKVENEEHGAPELWCHPACRVGQCVVVFSQAPSGRAPLSPSLNSRPSPISATPPALVPETREYRSQSPVRSMDEAPCVNGRWGTLRPRAQRQTPSGSREGSLSPARGDGSPILNGGSLSPGTAAVGGSLDSPVQAISPSTPSAPEGYDLKIGLSLAPRRGSLPDQKDLRLGSIDLNWDLKPASSSNPMDGMDNRTVGGSMRHPPEQTNGVHTPPHVASALAGAVSPGALRRSLEAIKAMSSKGPSASAALSPPLGSSPGSPGSQSLSSGETVPIPRPGPAQGDGHSLPPIARRLGHHPPQSLNVGKPLYQSMNCKPMQMYVLDIKDTKEKGRVKWKVFNSSSVVGPPETSLHTVVQGRGELIIFGGLMDKKQNVKYYPKTNALYFVRAKR
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分子量
104.2 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
FBXO42, a member of the F-box protein family, plays a crucial role in the ubiquitin-proteasome system, which is essential for regulating protein degradation and cellular processes. It contains an F-box motif that enables its interaction with the Skp1-Cullin-F-box (SCF) ubiquitin ligase complex, facilitating the recognition and ubiquitination of target substrates. Research indicates that FBXO42 is involved in various biological functions, including cell cycle regulation, apoptosis, and signal transduction, which are vital for maintaining cellular homeostasis. Dysregulation of FBXO42 has been associated with several diseases, including cancer, where it may contribute to tumor progression and metastasis by altering the degradation of key regulatory proteins. Additionally, the unique substrate specificity of FBXO42 makes it a potential therapeutic target for designing novel cancer treatments. Recent studies have focused on the functional characterization and identification of FBXO42 substrates, providing insights into its mechanisms of action and potential roles in pathology. As a result, the recombinant protein expression of FBXO42 has gained interest for further exploration, particularly in understanding its interactions and effects on cellular pathways. This knowledge could pave the way for innovative approaches in targeted therapy and enhance our understanding of ubiquitin-mediated processes in health and disease.
