Analytical Data
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基因名
TUBA6
- Application
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别名
Tubulin alpha-1C chain. EC:3.6.5.-. Alpha-tubulin 6. Tubulin alpha-6 chain. Cleaved into: Detyrosinated tubulin alpha-1C chain
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9BQE3
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表达区间
1-449 aa
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氨基酸序列
MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGKHVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLDRIRKLADQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLTVAEITNACFEPANQMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAVAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDMAALEKDYEEVGADSADGEDEGEEY
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分子量
75.13 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TUBA6, a member of the tubulin family, has garnered attention due to its role in microtubule dynamics and cellular processes. Recent studies highlight its significance in neurogenesis and cellular signaling, particularly within the context of neurodegenerative diseases. The protein's unique structural features and expression patterns make it a potential biomarker for certain neurological conditions. Researchers are particularly interested in TUBA6's involvement in the assembly and stabilization of the microtubule network, which is crucial for maintaining cellular integrity and function. Moreover, alterations in TUBA6 expression have been linked to various pathologies, including Alzheimer's disease and other forms of dementia. The exploration of TUBA6 as a recombinant protein offers opportunities for understanding its functional mechanisms and interactions at a molecular level. By utilizing techniques such as gene cloning and protein expression systems, researchers aim to produce TUBA6 in sufficient quantities for detailed biochemical and biophysical characterization. These studies may reveal novel insights into the protein's role in cellular architecture and its potential as a therapeutic target. As such, ongoing research on TUBA6 not only enhances our comprehension of fundamental neurobiological processes but also holds promise for developing interventions in diseases characterized by microtubule dysfunction.
