Analytical Data
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Gene name
TUBA6
- Application
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Alternative Names
Tubulin alpha-1C chain. EC:3.6.5.-. Alpha-tubulin 6. Tubulin alpha-6 chain. Cleaved into: Detyrosinated tubulin alpha-1C chain
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9BQE3
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Expression Region
1-449 aa
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AA Sequence
MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGKHVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLDRIRKLADQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLTVAEITNACFEPANQMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAVAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDMAALEKDYEEVGADSADGEDEGEEY
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Molecular Weight
75.13 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TUBA6, a member of the tubulin family, has garnered attention due to its role in microtubule dynamics and cellular processes. Recent studies highlight its significance in neurogenesis and cellular signaling, particularly within the context of neurodegenerative diseases. The protein's unique structural features and expression patterns make it a potential biomarker for certain neurological conditions. Researchers are particularly interested in TUBA6's involvement in the assembly and stabilization of the microtubule network, which is crucial for maintaining cellular integrity and function. Moreover, alterations in TUBA6 expression have been linked to various pathologies, including Alzheimer's disease and other forms of dementia. The exploration of TUBA6 as a recombinant protein offers opportunities for understanding its functional mechanisms and interactions at a molecular level. By utilizing techniques such as gene cloning and protein expression systems, researchers aim to produce TUBA6 in sufficient quantities for detailed biochemical and biophysical characterization. These studies may reveal novel insights into the protein's role in cellular architecture and its potential as a therapeutic target. As such, ongoing research on TUBA6 not only enhances our comprehension of fundamental neurobiological processes but also holds promise for developing interventions in diseases characterized by microtubule dysfunction.
