Analytical Data
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基因名
BMP7
- Application
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别名
BMP7；OP1；Bone morphogenetic Protein 7
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P18075
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表达区间
315-431aa
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氨基酸序列
MANVAENSSSDQRQACKKHELYVSFRDLGWQDWIIAPEGYAAYYCEGECA FPLNSYMNATNHAIVQTLVHFINPETVPKPCCAPTQLNAISVLYFDDSSN VILKKYRNMVVRACGCH
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分子量
26 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
Bone morphogenetic protein 7 (BMP7), also known as osteogenic protein 1 (OP-1), is part of the transforming growth factor-beta (TGF-β) superfamily, playing a crucial role in bone formation and repair, as well as in various cellular processes such as differentiation and tissue homeostasis. Research on BMP7 has gained significant attention due to its potential therapeutic applications in regenerative medicine, particularly in orthopedic applications and the treatment of fractures, osteoarthritis, and other bone-related disorders. Recombinant BMP7 protein has been explored extensively for its ability to stimulate osteogenesis by promoting the differentiation of mesenchymal stem cells into osteoblasts, the cells responsible for bone formation. Moreover, BMP7 has demonstrated anti-inflammatory properties, making it a promising candidate for treating conditions characterized by excessive inflammation and tissue damage. The production of recombinant BMP7 in various expression systems, including bacteria, yeast, and mammalian cells, has facilitated its study and potential clinical applications. However, challenges remain in achieving optimal protein yield, bioactivity, and stability, necessitating ongoing research into its molecular mechanisms and interactions within the bone microenvironment. Understanding these factors can help enhance the efficacy and safety of BMP7-based therapies, paving the way for innovative treatments in orthopedic and regenerative medicine.
