Analytical Data
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Gene name
TUBA1A
- Application
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Alternative Names
TUBA1A
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q71U36
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Expression Region
1-451 aa
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AA Sequence
MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGKHVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLDRIRKLADQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLIGQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDMAALEKDYEEVGVDSVEGEGEEEGEEY
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Molecular Weight
57.1 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TUBA1A, a member of the tubulin family, encodes an alpha-tubulin protein that is a critical component of microtubules, which are essential for various cellular processes, including cell division, intracellular transport, and maintenance of cell shape. Mutations in TUBA1A have been linked to a range of neurodevelopmental disorders, highlighting its significance in the proper functioning of the nervous system. Understanding the structure and function of TUBA1A is crucial for elucidating its role in these diseases. Researchers have focused on generating recombinant TUBA1A proteins to study their properties and interactions in vitro. These studies aim to decipher the molecular mechanisms underlying TUBA1A-related pathologies. By using techniques such as X-ray crystallography and cryo-electron microscopy, scientists are gaining insights into the structural variations caused by mutations and their impact on microtubule dynamics. The findings from TUBA1A recombinant protein studies hold potential for developing therapeutic strategies for the associated neurodevelopmental disorders, providing a better understanding of how alterations in tubulin dynamics can lead to significant clinical manifestations. Overall, the research on TUBA1A recombinant proteins not only enhances our fundamental knowledge of tubulin biology but also paves the way for potential clinical applications.
