Analytical Data
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Gene name
TTYH1
- Application
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Alternative Names
TTYH1; Protein tweety homolog 1; hTTY1
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9H313
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Expression Region
1-239 aa
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AA Sequence
MWLAYVLLLLLELLVCLFTLLGLAKQSKWLVIVMTVMSLLVLVLSWGSMGLEAATAVGLSDFCSNPDPYVLNLTQEETGLSSDILSYYLLCNRAVSNPFQQRLTLSQRALANIHSQLLGLEREAVPQFPSAQKPLLSLEETLNVTEGNFHQLVALLHCRSLHKDYGAALRGLCEDALEGLLFLLLFSLLSAGALATALCSLPRAWALFPPSDDYDDTDDDDPFNPQQESKRFVQWQSSI
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Molecular Weight
52.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TTYH1 (Ttyh1, also known as TTYH1) is a member of the TREK/K2P channel family, which is known for its significant role in modulating neuronal excitability and various physiological processes. There has been increasing interest in TTYH1 due to its potential involvement in the pathogenesis of several neurodegenerative diseases and psychiatric disorders. Recent studies suggest that TTYH1 might play a critical role in regulating ion homeostasis and cellular signaling pathways, making it a promising target for therapeutic interventions. Research on the recombinant TTYH1 protein has focused on elucidating its structure-function relationship, as well as its interaction with small molecules and other proteins. Understanding the molecular mechanisms of TTYH1 may provide insights into its roles in brain function and disease, paving the way for the development of novel strategies for treating conditions related to dysregulated ion channel activity. As such, the study of TTYH1 recombinant protein is not only vital for basic neuroscience but also holds potential for translational applications in drug discovery and the development of targeted therapies.
