Analytical Data
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基因名
TTC8
- Application
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别名
Bardet Biedl syndrome 8 Protein; Bardet Biedl syndrome type 8; Bardet-Biedl syndrome 8 Protein; BBS8; RP51; Tetratricopeptide repeat domain 8; Tetratricopeptide repeat Protein 8; TPR repeat Protein 8; TTC 8; Ttc8; TTC8_HUMAN
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8TAM2
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表达区间
1-541 aa
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氨基酸序列
MSSEMEPLLL AWSYFRRRKF QLCADLCTQM LEKSPYDQEP DPELPVHQAA WILKARALTE MVYIDEIDVD QEGIAEMMLD ENAIAQVPRP GTSLKLPGTN QTGGPSQAVR PITQAGRPIT GFLRPSTQSG RPGTMEQAIR TPRTAYTARP ITSSSGRFVR LGTASMLTSP DGPFINLSRL NLTKYSQKPK LAKALFEYIF HHENDVKTIH LEDVVLHLGI YPFLLRNKNH IEKNALDLAA LSTEHSQYKD WWWKVQIGKC YYRLGMYREA EKQFKSALKQ QEMVDTFLYL AKVYVSLDQP VTALNLFKQG LDKFPGEVTL LCGIARIYEE MNNMSSAAEY YKEVLKQDNT HVEAIACIGS NHFYSDQPEI ALRFYRRLLQ MGIYNGQLFN NLGLCCFYAQ QYDMTLTSFE RALSLAENEE EAADVWYNLG HVAVGIGDTN LAHQCFRLAL VNNNNHAEAY NNLAVLEMRK GHVEQARALL QTASSLAPHM YEPHFNFATI SDKIGDLQRS YVAAQKSEAA FPDHVDTQHL IKQLRQHFAM L
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分子量
61.5 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TTC8, also known as Tetra-Tricopeptide Repeat-containing Protein 8, is a member of the TTC family of proteins characterized by the presence of multiple tetratricopeptide repeats (TPRs). These TPRs play critical roles in protein-protein interactions, which are essential for various cellular processes. Research into TTC8 has gained attention due to its association with Bardet-Biedl syndrome (BBS), a genetic disorder characterized by obesity, retinal degeneration, polydactyly, and renal abnormalities. Mutations in the TTC8 gene have been linked to a subset of BBS cases, suggesting that TTC8 is crucial for ciliary function and the regulation of intracellular signaling pathways. Recent studies have focused on elucidating the molecular mechanisms underlying TTC8's role in ciliogenesis and its impact on the pathophysiology of ciliary-related diseases. Investigating the recombinant form of TTC8 enables researchers to better understand its structure-function relationships and potential interactions with other ciliary proteins. Furthermore, the expression and purification of TTC8 recombinant protein provides valuable insights into its functional mechanisms, paving the way for potential therapeutic interventions for BBS and related disorders. Overall, the study of TTC8 is significant not only for advancing our knowledge of ciliary biology but also for its implications in understanding the genetic basis of complex human diseases.
