Analytical Data
-
Gene name
CASP8AP2
- Application
-
Alternative Names
CASP8AP2；FLASH；KIAA1315；RIP25；CASP8-associated Protein 2
-
Species
Human
-
Source
E. coli
-
Tag
His tag N-Terminus
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
Q9UKL3
-
Expression Region
全长
-
AA Sequence
full
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
CASP8AP2, also known as caspase-8 associated protein 2, is a protein that plays a critical role in regulating apoptosis and cellular stress responses. Research has shown that CASP8AP2 interacts with caspase-8, a key enzyme in the apoptosis signaling pathway, suggesting a significant function in modulating cell death and survival. Understanding the function of CASP8AP2 is vital due to its potential implications in various pathological conditions, including cancer, neurodegenerative disorders, and autoimmune diseases, where dysregulation of apoptosis can lead to abnormal cell proliferation or death. Recent studies have focused on the recombinant expression of CASP8AP2 to investigate its structural and functional properties, enabling a deeper understanding of its role in apoptotic signaling. By producing recombinant CASP8AP2, researchers can analyze its interaction with caspase-8 and other associated proteins, providing insights into its mechanisms of action. This knowledge could pave the way for the development of novel therapeutic strategies aimed at targeting apoptosis-related pathways in diseases characterized by impaired cell death. Furthermore, the ability to manipulate CASP8AP2 levels can enhance our understanding of cellular stress responses and their implications for disease progression, making it a target of significant interest in biomedical research. Overall, the exploration of recombinant CASP8AP2 not only contributes to the fundamental understanding of apoptosis but also holds promise for therapeutic advancements in diseases where apoptosis plays a crucial role.
