Analytical Data
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基因名
FBXL10
- Application
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别名
[Histone-H3]-lysine-36 demethylase 1B; CXXC-type zinc finger protein 2; CXXC2; F box and leucine rich repeat protein 10; F box protein FBL10; F-box and leucine-rich repeat protein 10; F-box protein FBL10; F-box/LRR-repeat protein 10; Fbl10; FBXL10; JEMMA (Jumonji domain EMSY interactor methyltransferase motif) protein; JHDM1B; JmjC domain-containing histone demethylation protein 1B; Jumonji C domain containing histone demethylase 1B
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8NHM5
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表达区间
457-555aa
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氨基酸序列
LGKKPKAPALRFLKRTLSNESEESVKSTTLAVDYPKTPTGSPATEVSAKWTHLTEFELKGLKALVEKLESLPENKKCVPEGIEDPQALLEGVKNVLKEH
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分子量
36.63 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
FBXL10, also known as F-box and leucine-rich repeat protein 10, is a member of the F-box protein family, which plays a crucial role in the regulation of the ubiquitin-proteasome system. This system is essential for controlling various cellular processes, including protein degradation, cell cycle progression, and response to environmental stimuli. FBXL10 specifically functions as a substrate recognition component in E3 ubiquitin ligase complexes, targeting various proteins for ubiquitination and subsequent degradation. Research has shown that dysregulation of FBXL10 is implicated in several pathological conditions, including cancer and developmental disorders, making it a potential biomarker and therapeutic target. Furthermore, recent studies have highlighted its role in the modulation of epigenetic states through interaction with chromatin remodeling complexes. The recombination and expression of FBXL10 as a fusion protein in laboratory settings facilitates exploration into its molecular mechanisms and biological functions. By studying FBXL10, researchers aim to deepen our understanding of its contributions to cellular homeostasis, investigate its potential as a target for novel therapeutic interventions, and explore its utility in the development of diagnostic tools for diseases associated with its dysfunction. Such advances promise to shed light on the complex interplay between protein degradation pathways and disease, potentially leading to innovative strategies for treatment.
