Analytical Data
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Gene name
TSP50
- Application
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Alternative Names
Probable threonine protease PRSS50. EC:3.4.25.-. Cancer/testis antigen 20. Serine protease 50. Testis-specific protease-like Protein 50
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9UI38
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Expression Region
1-385 aa
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AA Sequence
MGRWCQTVARGQRPRTSAPSRAGALLLLLLLLRSAGCWGAGEAPGALSTADPADQSVQCVPKATCPSSRPRLLWQTPTTQTLPSTTMETQFPVSEGKVDPYRSCGFSYEQDPTLRDPEAVARRWPWMVSVRANGTHICAGTIIASQWVLTVAHCLIWRDVIYSVRVGSPWIDQMTQTASDVPVLQVIMHSRYRAQRFWSWVGQANDIGLLKLKQELKYSNYVRPICLPGTDYVLKDHSRCTVTGWGLSKADGMWPQFRTIQEKEVIILNNKECDNFYHNFTKIPTLVQIIKSQMMCAEDTHREKFCYELTGEPLVCSMEGTWYLVGLVSWGAGCQKSEAPPIYLQVSSYQHWIWDCLNGQALALPAPSRTLLLALPLPLSLLAAL
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Molecular Weight
67.98 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TSP50, or Testis-Specific Protein 50, is a recently identified protein that plays a crucial role in spermatogenesis and male fertility. Research interest in TSP50 has increased due to its unique expression pattern, which is confined to the testis, making it a potential molecular marker for testicular function and a target for infertility treatments. The protein is thought to be involved in the regulation of gene expression essential for sperm development and maturation. Given the rising rates of male infertility globally, understanding the mechanisms underlying TSP50's functionality could pave the way for novel therapeutic approaches. Additionally, TSP50 may hold promise as a biomarker for certain testicular cancers, given its specific expression in germ cells. Studies focusing on the biochemical properties of TSP50, its interactions with other cellular proteins, and its regulatory pathways could provide insights into male reproductive health and identify potential targets for intervention in infertility and cancer therapies. Overall, TSP50 represents a significant focus of research aimed at unraveling its role in male reproductive biology and its potential applications in clinical settings.
