Analytical Data
-
Gene name
TRIP4
- Application
-
Alternative Names
Activating signal cointegrator 1; ASC 1; ASC-1; HsT17391; Thyroid hormone receptor interactor 4; Thyroid receptor interacting Protein 4; Thyroid receptor-interacting Protein 4; TR-interacting Protein 4; TRIP 4; TRIP-4; Trip4; TRIP4_HUMAN; ZC2HC5; Zinc finger C2HC5 type
-
Species
Human
-
Source
E. coli
-
Tag
His tag N-Terminus
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
Q15650
-
Expression Region
2-581 aa
-
AA Sequence
AVAGAVSGE PLVHWCTQQL RKTFGLDVSE EIIQYVLSIE SAEEIREYVT DLLQGNEGKK GQFIEELITK WQKNDQELIS DPLQQCFKKD EILDGQKSGD HLKRGRKKGR NRQEVPAFTE PDTTAEVKTP FDLAKAQENS NSVKKKTKFV NLYTREGQDR LAVLLPGRHP CDCLGQKHKL INNCLICGRI VCEQEGSGPC LFCGTLVCTH EEQDILQRDS NKSQKLLKKL MSGVENSGKV DISTKDLLPH QELRIKSGLE KAIKHKDKLL EFDRTSIRRT QVIDDESDYF ASDSNQWLSK LERETLQKRE EELRELRHAS RLSKKVTIDF AGRKILEEEN SLAEYHSRLD ETIQAIANGT LNQPLTKLDR SSEEPLGVLV NPNMYQSPPQ WVDHTGAASQ KKAFRSSGFG LEFNSFQHQL RIQDQEFQEG FDGGWCLSVH QPWASLLVRG IKRVEGRSWY TPHRGRLWIA ATAKKPSPQE VSELQATYRL LRGKDVEFPN DYPSGCLLGC VDLIDCLSQK QFKEQFPDIS QESDSPFVFI CKNPQEMVVK FPIKGNPKIW KLDSKIHQGA KKGLMKQNKA V
-
Molecular Weight
66.1 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
TRIP4, or Thyroid hormone Receptor Interacting Protein 4, is a crucial protein involved in the regulation of various cellular processes, including gene expression and signal transduction pathways. Initially identified as a coactivator for thyroid hormone receptors, TRIP4 has garnered attention for its role in mediating the effects of thyroid hormones on metabolism, development, and differentiation. Recent studies suggest that TRIP4 is not only associated with thyroid hormone signaling but also interacts with other nuclear receptors, thus influencing diverse biological functions. Additionally, its involvement in various diseases, including cancer and metabolic disorders, highlights the importance of understanding TRIP4's mechanisms of action. Researchers have focused on elucidating the structure-function relationships of TRIP4 to better comprehend its regulatory roles and potential as a therapeutic target. The advancement in recombinant protein technology has enabled the production and characterization of TRIP4, facilitating in-depth studies of its structure, interactions, and impact on cellular pathways. Such insights could lead to novel strategies for treating diseases linked to dysregulated thyroid hormone signaling and TRIP4 dysfunction. Overall, the ongoing research on TRIP4 aims to unravel its intricate biological roles and contribute to our understanding of its significance in health and disease.
