Analytical Data
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基因名
IRF4
- Application
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别名
IRF4；MUM1；Interferon regulatory factor 4
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q15306
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表达区间
1-451aa
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氨基酸序列
MNLEGGGRGGEFGMSAVSCGNGKLRQWLIDQIDSGKYPGLVWENEEKSIF RIPWKHAGKQDYNREEDAALFKAWALFKGKFREGIDKPDPPTWKTRLRCA LNKSNDFEELVERSQLDISDPYKVYRIVPEGAKKGAKQLTLEDPQMSMSH PYTMTTPYPSLPAQQVHNYMMPPLDRSWRDYVPDQPHPEIPYQCPMTFGP RGHHWQGPACENGCQVTGTFYACAPPESQAPGVPTEPSIRSAEALAFSDC RLHICLYYREILVKELTTSSPEGCRISHGHTYDASNLDQVLLPYPEDNGQ RKNIEKLLSHLERGVVPWMAPDGLYAKRLCQSRIYWDGPLALCNDRPNKL ERDQTCKLFDTQQFLSELQAFAHHGRSLPRFQVTLCFGEEFPDPQRQRKL ITAHVEPLLARQLYYFAQQNSGHFLRGYDLPEHISNPEDYHRSIRHSSIQ E
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分子量
75 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
IRF4 (Interferon Regulatory Factor 4) is a critical transcription factor that plays a significant role in the immune system, particularly in the regulation of immune responses. It is primarily expressed in lymphocytes, including B cells and T cells, where it regulates the differentiation, proliferation, and function of these cells. Research has indicated that IRF4 is essential for the development of distinct immune lineages, such as plasma cells and follicular helper T cells, and it significantly influences the production of immunoglobulins. Given its pivotal role in adaptive immunity, IRF4 has also been implicated in various diseases, including autoimmune disorders and cancers, particularly lymphomas. The investigation of IRF4 recombinant protein serves multiple objectives, such as elucidating its structural properties, understanding its interaction with other proteins, and exploring its potential as a therapeutic target. By using recombinant technology, researchers can produce the IRF4 protein in a controlled environment, facilitating studies on its functional dynamics and involvement in immune regulation. Furthermore, as scientists seek to develop novel immunotherapies, characterizing the function of IRF4 through its recombinant form may reveal insights into its potential manipulation for clinical benefit. Thus, the study of IRF4 recombinant protein is instrumental in bridging fundamental immunological knowledge with therapeutic applications, aiming to harness the immune system for the treatment of various diseases.
