Analytical Data
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Gene name
ZNF46
- Application
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Alternative Names
Zinc finger and BTB domain-containing Protein 25. Zinc finger Protein 46. Zinc finger Protein KUP
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P24278
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Expression Region
1-435 aa
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AA Sequence
MDTASHSLVLLQQLNMQREFGFLCDCTVAIGDVYFKAHRAVLAAFSNYFKMIFIHQTSECIKIQPTDIQPDIFSYLLHIMYTGKGPKQIVDHSRLEEGIRFLHADYLSHIATEMNQVFSPETVQSSNLYGIQISTTQKTVVKQGLEVKEAPSSNSGNRAAVQGDHPQLQLSLAIGLDDGTADQQRACPATQALEEHQKPPVSIKQERCDPESVISQSHPSPSSEVTGPTFTENSVKIHLCHYCGERFDSRSNLRQHLHTHVSGSLPFGVPASILESNDLGEVHPLNENSEALECRRLSSFIVKENEQQPDHTNRGTTEPLQISQVSLISKDTEPVELNCNFSFSRKRKMSCTICGHKFPRKSQLLEHMYTHKGKSYRYNRCQRFGNALAQRFQPYCDSWSDVSLKSSRLSQEHLDLPCALESELTQENVDTILVE
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Molecular Weight
73.37 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ZNF46 (Zinc Finger Protein 46) is a member of the zinc finger protein family, which plays crucial roles in various biological processes, including gene regulation, cell differentiation, and apoptosis. Recent studies have highlighted its significance in modulating transcriptional activity and its potential involvement in developmental disorders and certain types of cancer. The ability of ZNF46 to interact with specific DNA sequences suggests that it may serve as a transcription factor, influencing the expression of target genes. Despite its importance, the biochemical properties and functional mechanisms of ZNF46 remain inadequately understood. Research into recombinant ZNF46 proteins aims to elucidate its structural characteristics and interaction profiles, facilitating the identification of its relevant biological pathways. Through techniques such as crystallography and nuclear magnetic resonance (NMR), scientists are exploring the protein's conformation and binding affinities. Investigating ZNF46 at the molecular level may not only shed light on its role in health and disease but also unveil potential therapeutic targets for interventions in ZNF46-related pathologies. Overall, the study of ZNF46 recombinant protein is poised to contribute significantly to our understanding of gene regulation mechanisms and the development of novel therapeutic strategies.
