Analytical Data
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Gene name
HMGN1
- Application
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Alternative Names
HMGN1；HMG14；Non-histone chromosomal Protein HMG-14
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P05114
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Expression Region
1-100aa
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AA Sequence
MPKRKVSSTEGAAKEEPKRRSARLSAKPPAKVEAKPKKAAAKDKSSDKKV QTKGKRGAKGKQAEVANQETKEDLPAENGETKTEESPASDEAGEKEAKSD
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Molecular Weight
37 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HMGN1, or high mobility group nucleosome-binding domain 1, is a highly conserved protein that plays a crucial role in the regulation of chromatin structure and gene expression. It is known to bind specifically to nucleosomes, facilitating the dynamic repositioning of histones and influencing transcriptional activity. Research has revealed that HMGN1 can modulate various cellular processes, including cell proliferation, differentiation, and response to stress, making it a significant focus in the study of cellular mechanisms underlying diseases such as cancer and inflammation. Moreover, abnormal expression levels of HMGN1 have been associated with various pathological conditions, indicating its potential as a biomarker and therapeutic target. The production of recombinant HMGN1 protein has become essential for unraveling its functional mechanisms and interactions with other cellular molecules. Current studies often employ recombinant techniques to generate HMGN1 in sufficient quantities for detailed biochemical assays, structural analyses, and cell-based experiments. This research aims to deepen our understanding of how HMGN1 influences chromatin dynamics and cellular responses, with the hope of uncovering new strategies for disease intervention and therapy. Exploring the applications of HMGN1 in drug development and targeted treatments remains a promising avenue for future research.
