Analytical Data
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Gene name
ATR
- Application
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Alternative Names
ATR；FRP1；Serine/threonine-Protein kinase ATR
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q13535
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Expression Region
2245-2610aa
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AA Sequence
MLKKLVEEATFSEILIPLQSVMIPTLPSILGTHANHASHEPFPGHWAYIA GFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCRLMEFNSL INKCLRKDAESRRRELHIRTYAVIPLNDECGIIEWVNNTAGLRPILTKLY KEKGVYMTGKELRQCMLPKSAALSEKLKVFREFLLPRHPPIFHEWFLRTF PDPTSWYSSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSLTGECVHVD FNCLFNKGETFEVPEIVPFRLTHNMVNGMGPMGTEGLFRRACEVTMRLMR DQREPLMSVLKTFLHDPLVEWSKPVKGHSKAPLNETGEVVNEKAKTHVLD IEQRLQGVIK TRNRVT
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Molecular Weight
70 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
ATR (ATM and Rad3 related protein) is a key regulator of the cellular response to DNA damage and plays a crucial role in maintaining genomic stability. It belongs to the phosphatidylinositol 3-kinase-related kinase (PIKK) family and is particularly important in the activation of the DNA damage checkpoint response. Research into ATR has gained prominence due to its involvement in various cellular processes, including DNA replication, repair, and cell cycle regulation. Mutations or dysregulation of ATR are linked to several diseases, including cancer, where it can contribute to tumorigenesis by allowing rapidly dividing cells to bypass essential checkpoints. As a result, ATR has emerged as a promising target for cancer therapy, particularly in combination with other treatments such as chemotherapy and radiation, which induce DNA damage. Inhibitors of ATR are being developed and tested in preclinical and clinical trials, aiming to enhance the effectiveness of existing therapies by exploiting the synthetic lethality concept. Moreover, understanding the structural and functional aspects of ATR, including its role in signaling pathways and interactions with other proteins involved in DNA repair, is essential for the rational design of drugs. Collectively, these research efforts underscore the importance of ATR in both basic biology and therapeutic innovation, paving the way for novel strategies in cancer treatment and precision medicine.
