Analytical Data
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基因名
ATR
- Application
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别名
ATR；FRP1；Serine/threonine-Protein kinase ATR
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q13535
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表达区间
2245-2610aa
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氨基酸序列
MLKKLVEEATFSEILIPLQSVMIPTLPSILGTHANHASHEPFPGHWAYIA GFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCRLMEFNSL INKCLRKDAESRRRELHIRTYAVIPLNDECGIIEWVNNTAGLRPILTKLY KEKGVYMTGKELRQCMLPKSAALSEKLKVFREFLLPRHPPIFHEWFLRTF PDPTSWYSSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSLTGECVHVD FNCLFNKGETFEVPEIVPFRLTHNMVNGMGPMGTEGLFRRACEVTMRLMR DQREPLMSVLKTFLHDPLVEWSKPVKGHSKAPLNETGEVVNEKAKTHVLD IEQRLQGVIK TRNRVT
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分子量
70 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ATR (ATM and Rad3 related protein) is a key regulator of the cellular response to DNA damage and plays a crucial role in maintaining genomic stability. It belongs to the phosphatidylinositol 3-kinase-related kinase (PIKK) family and is particularly important in the activation of the DNA damage checkpoint response. Research into ATR has gained prominence due to its involvement in various cellular processes, including DNA replication, repair, and cell cycle regulation. Mutations or dysregulation of ATR are linked to several diseases, including cancer, where it can contribute to tumorigenesis by allowing rapidly dividing cells to bypass essential checkpoints. As a result, ATR has emerged as a promising target for cancer therapy, particularly in combination with other treatments such as chemotherapy and radiation, which induce DNA damage. Inhibitors of ATR are being developed and tested in preclinical and clinical trials, aiming to enhance the effectiveness of existing therapies by exploiting the synthetic lethality concept. Moreover, understanding the structural and functional aspects of ATR, including its role in signaling pathways and interactions with other proteins involved in DNA repair, is essential for the rational design of drugs. Collectively, these research efforts underscore the importance of ATR in both basic biology and therapeutic innovation, paving the way for novel strategies in cancer treatment and precision medicine.
