Analytical Data
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Gene name
TRIM46
- Application
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Alternative Names
fibronectin type-III and C-terminal SPRY motif Protein; Gene Y Protein; GeneY; TRI46_HUMAN; TRIFIC; Trim46; Tripartite; Tripartite motif containing Protein 46; Tripartite motif-containing Protein 46; Tripartite. fibronectin type III and C terminal SPRY motif Protein
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q7Z4K8
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Expression Region
1-759 aa
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AA Sequence
MAEGEDMQTF TSIMDALVRI STSMKNMEKE LLCPVCQEMY KQPLVLPCTH NVCQACAREV LGQQGYIGHG GDPSSEPTSP ASTPSTRSPR LSRRTLPKPD RLDRLLKSGF GTYPGRKRGA LHPQVIMFPC PACQGDVELG ERGLAGLFRN LTLERVVERY RQSVSVGGAI LCQLCKPPPL EATKGCTECR ATFCNECFKL FHPWGTQKAQ HEPTLPTLSF RPKGLMCPDH KEEVTHYCKT CQRLVCQLCR VRRTHSGHKI TPVLSAYQAL KDKLTKSLTY ILGNQDTVQT QICELEEAVR HTEVSGQQAK EEVSQLVRGL GAVLEEKRAS LLQAIEECQQ ERLARLSAQI QEHRSLLDGS GLVGYAQEVL KETDQPCFVQ AAKQLHNRIA RATEALQTFR PAASSSFRHC QLDVGREMKL LTELNFLRVP EAPVIDTQRT FAYDQIFLCW RLPPHSPPAW HYTVEFRRTD VPAQPGPTRW QRREEVRGTS ALLENPDTGS VYVLRVRGCN KAGYGEYSED VHLHTPPAPV LHFFLDSRWG ASRERLAISK DQRAVRSVPG LPLLLAADRL LTGCHLSVDV VLGDVAVTQG RSYWACAVDP ASYLVKVGVG LESKLQESFQ GAPDVISPRY DPDSGHDSGA EDATVEASPP FAFLTIGMGK ILLGSGASSN AGLTGRDGPT AGCTVPLPPR LGICLDYERG RVSFLDAVSF RGLLECPLDC SGPVCPAFCF IGGGAVQLQE PVGTKPERKV TIGGFAKLD
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Molecular Weight
83.4 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
TRIM46 (Tripartite Motif Containing 46) is a member of the TRIM family of proteins, which are characterized by a RING domain followed by one or more B-box motifs and a coiled-coil region. TRIM proteins are implicated in various cellular processes, including cell proliferation, differentiation, and tumorigenesis. TRIM46, in particular, has garnered attention due to its potential roles in regulating microtubule dynamics and maintaining cellular architecture. Studies suggest that TRIM46 may play significant roles in neurogenesis by influencing neuronal differentiation and migration. Additionally, emerging evidence indicates that TRIM46 is involved in the promotion of cancer cell invasion and metastasis, hinting at its potential as a biomarker for aggressive tumors. The understanding of TRIM46's structure-function relationship and its interactions with other cellular pathways is crucial for deciphering its biological roles. Consequently, research on TRIM46 recombinant proteins is vital for elucidating its mechanisms of action and exploring its therapeutic potential in cancer and neurodevelopmental disorders. The ongoing investigations into TRIM46 contribute to a broader understanding of TRIM family proteins, highlighting their significance in health and disease.
